Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization
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Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survivalFGF4 independent derivation of trophoblast stem cells from the common voleStructural basis for fibroblast growth factor receptor 2 activation in Apert syndromeStructural insights into the Slit-Robo complexStructural basis by which alternative splicing confers specificity in fibroblast growth factor receptorsGentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitorsStructural basis by which alternative splicing modulates the organizer activity of FGF8 in the brainInsights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuityFibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFsA molecular mechanism for the heparan sulfate dependence of slit-robo signalingDecreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and miceFGF-10 and its receptor exhibit bidirectional paracrine targeting to urothelial and smooth muscle cells in the lower urinary tractEffect of FGF-binding protein 3 on vascular permeabilityLiver-specific activities of FGF19 require Klotho betaNovel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1Syndecan-syntenin-ALIX regulates the biogenesis of exosomesEnhanced levels of Hsulf-1 interfere with heparin-binding growth factor signaling in pancreatic cancer.Fibroblast growth factor-2 binds to small heparin-derived oligosaccharides and stimulates a sustained phosphorylation of p42/44 mitogen-activated protein kinase and proliferation of rat mammary fibroblastsBiosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and propertiesFibroblast growth factorsIdentification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesisSulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancerAnalysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerizationCell signaling by receptor tyrosine kinasesThe alternatively spliced acid box region plays a key role in FGF receptor autoinhibitionNeutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal modelsGlypican-1 is frequently overexpressed in human gliomas and enhances FGF-2 signaling in glioma cellsQSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signalingMolecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily membersMarine Non-Glycosaminoglycan Sulfated Glycans as Potential PharmaceuticalsHeparan sulfate and heparin interactions with proteinsGrowth Factor-Extracellular Matrix Interactions Regulate Wound RepairExtracellular distribution of diffusible growth factors controlled by heparan sulfate proteoglycans during mammalian embryogenesisSyndecan-4 signaling at a glanceInteractions of the Extracellular Matrix and Progenitor Cells in Cutaneous Wound HealingExploring mechanisms of FGF signalling through the lens of structural biology3-OST-7 regulates BMP-dependent cardiac contractionTransport of fibroblast growth factor 2 in the pericellular matrix is controlled by the spatial distribution of its binding sites in heparan sulfateAdaptation of tick-borne encephalitis virus to BHK-21 cells results in the formation of multiple heparan sulfate binding sites in the envelope protein and attenuation in vivoCrystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition
P2860
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P2860
Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization
description
2000 nî lūn-bûn
@nan
2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Crystal structure of a ternary ...... FGFR binding and dimerization
@ast
Crystal structure of a ternary ...... FGFR binding and dimerization
@en
Crystal structure of a ternary ...... FGFR binding and dimerization
@en-gb
Crystal structure of a ternary ...... FGFR binding and dimerization
@nl
type
label
Crystal structure of a ternary ...... FGFR binding and dimerization
@ast
Crystal structure of a ternary ...... FGFR binding and dimerization
@en
Crystal structure of a ternary ...... FGFR binding and dimerization
@en-gb
Crystal structure of a ternary ...... FGFR binding and dimerization
@nl
prefLabel
Crystal structure of a ternary ...... FGFR binding and dimerization
@ast
Crystal structure of a ternary ...... FGFR binding and dimerization
@en
Crystal structure of a ternary ...... FGFR binding and dimerization
@en-gb
Crystal structure of a ternary ...... FGFR binding and dimerization
@nl
P2093
P3181
P1433
P1476
Crystal structure of a ternary ...... FGFR binding and dimerization
@en
P2093
A N Plotnikov
A V Eliseenkova
J Schlessinger
M Mohammadi
O A Ibrahimi
P304
P3181
P356
10.1016/S1097-2765(00)00073-3
P407
P577
2000-09-01T00:00:00Z