The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation
about
Elucidating a key anti-HIV-1 and cancer-associated axis: the structure of CCL5 (Rantes) in complex with CCR5.Generic GPCR residue numbers - aligning topology maps while minding the gapsCutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2.Identification of proline residues in or near the transmembrane helices of the human breast cancer resistance protein (BCRP/ABCG2) that are important for transport activity and substrate specificity.Structure modeling of the chemokine receptor CCR5: implications for ligand binding and selectivity.The dimeric transmembrane domain of prolyl dipeptidase DPP-IV contributes to its quaternary structure and enzymatic activities.The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors.Structural Analysis of Chemokine Receptor-Ligand Interactions.Constitutively active CCR5 chemokine receptors differ in mediating HIV envelope-dependent fusion.New insights into the mechanisms whereby low molecular weight CCR5 ligands inhibit HIV-1 infectionComparison of three GPCR structural templates for modeling of the P2Y12 nucleotide receptor.Allosteric model of maraviroc binding to CC chemokine receptor 5 (CCR5).CCR5 mutations distinguish N-terminal modifications of RANTES (CCL5) with agonist versus antagonist activity.Characterizing the Murine Leukemia Virus Envelope Glycoprotein Membrane-Spanning Domain for Its Roles in Interface Alignment and FusogenicityFunctional analysis of the murine cytomegalovirus chemokine receptor homologue M33: ablation of constitutive signaling is associated with an attenuated phenotype in vivo.Use of G-protein-coupled and -uncoupled CCR5 receptors by CCR5 inhibitor-resistant and -sensitive human immunodeficiency virus type 1 variants.The seventh transmembrane domains of the delta and kappa opioid receptors have different accessibility patterns and interhelical interactions.Chemokine receptors and other G protein-coupled receptors.C-C chemokine receptor type five (CCR5): An emerging target for the control of HIV infection.Structural determinants for the interaction of formyl peptide receptor 2 with peptide ligands.Biology and clinical relevance of chemokines and chemokine receptors CXCR4 and CCR5 in human diseases.Targeting chemokine receptors in allergic disease.Pharmacological modulation of chemokine receptor function.Conserved activation pathways in G-protein-coupled receptors.Impact of helix irregularities on sequence alignment and homology modeling of G protein-coupled receptors.Chemokine receptor modeling: an interdisciplinary approach to drug design.Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5).New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model.Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3.Evidence for conformational changes within DsbD: possible role for membrane-embedded proline residues.Structure-activity analysis of ginkgolide binding in the glycine receptor pore.Influence of the environment in the conformation of alpha-helices studied by protein database search and molecular dynamics simulations.Ser and Thr residues modulate the conformation of pro-kinked transmembrane alpha-helices.Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist.Conserved extracellular cysteine residues and cytoplasmic loop-loop interplay are required for functionality of the heptahelical MLO proteinEvolutionary Analysis of Functional Divergence among Chemokine Receptors, Decoy Receptors, and Viral Receptors.Reversed binding of a small molecule ligand in homologous chemokine receptors - differential role of extracellular loop 2.Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment.Molecular dynamics simulations reveal that AEDANS is an inert fluorescent probe for the study of membrane proteins.
P2860
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P2860
The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
The TXP motif in the second tr ...... f chemokine-induced activation
@ast
The TXP motif in the second tr ...... f chemokine-induced activation
@en
The TXP motif in the second tr ...... f chemokine-induced activation
@en-gb
The TXP motif in the second tr ...... f chemokine-induced activation
@nl
type
label
The TXP motif in the second tr ...... f chemokine-induced activation
@ast
The TXP motif in the second tr ...... f chemokine-induced activation
@en
The TXP motif in the second tr ...... f chemokine-induced activation
@en-gb
The TXP motif in the second tr ...... f chemokine-induced activation
@nl
prefLabel
The TXP motif in the second tr ...... f chemokine-induced activation
@ast
The TXP motif in the second tr ...... f chemokine-induced activation
@en
The TXP motif in the second tr ...... f chemokine-induced activation
@en-gb
The TXP motif in the second tr ...... f chemokine-induced activation
@nl
P2093
P2860
P50
P921
P356
P1476
The TXP motif in the second tr ...... f chemokine-induced activation
@en
P2093
C Blanpain
C Govaerts
J A Ballesteros
P2860
P304
P356
10.1074/JBC.M011670200
P407
P577
2001-04-20T00:00:00Z