Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly
about
Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous systemBinding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated musclesObscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurinA mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domainα-Synemin localizes to the M-band of the sarcomere through interaction with the M10 region of titinInteractions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnoverObscurin targets ankyrin-B and protein phosphatase 2A to the cardiac M-lineMolecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titinObscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnoverInteraction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulinObscurin is a ligand for small ankyrin 1 in skeletal muscleDifferent obscurin isoforms localize to distinct sites at sarcomeresTitin-based tension in the cardiac sarcomere: molecular origin and physiological adaptationsLarge isoforms of UNC-89 (obscurin) are required for muscle cell architecture and optimal calcium release in Caenorhabditis elegansStructural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complexKrp1 (Sarcosin) promotes lateral fusion of myofibril assembly intermediates in cultured mouse cardiomyocytesThe A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophyWhole-genome sequence analyses of Western Central African Pygmy hunter-gatherers reveal a complex demographic history and identify candidate genes under positive natural selectionNovex-3, the tiny titin of muscle.Bin1 SRC homology 3 domain acts as a scaffold for myofiber sarcomere assemblyA LIM-9 (FHL)/SCPL-1 (SCP) complex interacts with the C-terminal protein kinase regions of UNC-89 (obscurin) in Caenorhabditis elegans muscle.Titin as a giant scaffold for integrating stress and Src homology domain 3-mediated signaling pathways: the clustering of novel overlap ligand motifs in the elastic PEVK segment.Biophysical characterization of naturally occurring titin M10 mutationsSel1 repeat protein LpnE is a Legionella pneumophila virulence determinant that influences vacuolar traffickingDefining elastic fiber interactions by molecular fishing: an affinity purification and mass spectrometry approach.Targeted deletion of the zebrafish obscurin A RhoGEF domain affects heart, skeletal muscle and brain developmentDevelopmental expression and differential cellular localization of obscurin and obscurin-associated kinase in cardiac muscle cells.Loss of giant obscurins promotes breast epithelial cell survival through apoptotic resistanceMolecular structure of sarcomere-to-membrane attachment at M-Lines in C. elegans muscleObscure functions: the location-function relationship of obscurins.An historical perspective of the discovery of titin filamentsObscurin determines the architecture of the longitudinal sarcoplasmic reticulum.Calmodulin signaling via the IQ motif.The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin.Electrostatic interactions mediate binding of obscurin to small ankyrin 1: biochemical and molecular modeling studies.Molecular etiology of idiopathic cardiomyopathy.The parathyroid hormone-responsive B1 gene is interrupted by a t(1;7)(q42;p15) breakpoint associated with Wilms' tumour.Fishing out proteins that bind to titinWhole transcriptome analyses of six thoroughbred horses before and after exercise using RNA-Seq.Loss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cells
P2860
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P2860
Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly
description
2001 nî lūn-bûn
@nan
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
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2001年の論文
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2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
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2001年论文
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name
Obscurin, a giant sarcomeric R ...... involved in sarcomere assembly
@ast
Obscurin, a giant sarcomeric R ...... involved in sarcomere assembly
@en
Obscurin, a giant sarcomeric R ...... involved in sarcomere assembly
@en-gb
Obscurin, a giant sarcomeric R ...... involved in sarcomere assembly
@nl
type
label
Obscurin, a giant sarcomeric R ...... involved in sarcomere assembly
@ast
Obscurin, a giant sarcomeric R ...... involved in sarcomere assembly
@en
Obscurin, a giant sarcomeric R ...... involved in sarcomere assembly
@en-gb
Obscurin, a giant sarcomeric R ...... involved in sarcomere assembly
@nl
prefLabel
Obscurin, a giant sarcomeric R ...... involved in sarcomere assembly
@ast
Obscurin, a giant sarcomeric R ...... involved in sarcomere assembly
@en
Obscurin, a giant sarcomeric R ...... involved in sarcomere assembly
@en-gb
Obscurin, a giant sarcomeric R ...... involved in sarcomere assembly
@nl
P2860
P50
P356
P1476
Obscurin, a giant sarcomeric R ...... involved in sarcomere assembly
@en
P2860
P304
P356
10.1083/JCB.200102110
P407
P577
2001-07-09T00:00:00Z