Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins
about
Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1uIdentifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class INanoparticle-based targeted therapeutics in head-and-neck cancerProteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate AffinityCleaning up in the endoplasmic reticulum: ubiquitin in chargeControl of p97 function by cofactor bindingRhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin.A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins.Apolipoprotein B100 quality control and the regulation of hepatic very low density lipoprotein secretion.Sharpening rhomboid specificity by dimerisation and allostery.The C-terminal amino acid of the MHC-I heavy chain is critical for binding to Derlin-1 in human cytomegalovirus US11-induced MHC-I degradation.Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope.Differential evolution of members of the rhomboid gene family with conservative and divergent patterns.Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells.iRhom1 regulates proteasome activity via PAC1/2 under ER stressIntramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagySensitive Versatile Fluorogenic Transmembrane Peptide Substrates for Rhomboid Intramembrane Proteases.Transmembrane domain quality control systems operate at the endoplasmic reticulum and Golgi apparatusAlzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction.A ubiquitin-binding rhomboid protease aimed at ERADication.Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrateiRhoms; Its Functions and Essential Roles.Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFαIdentification of signaling pathways modulated by RHBDD2 in breast cancer cells: a link to the unfolded protein response.Mouse Mammary Tumor Virus Signal Peptide Uses a Novel p97-Dependent and Derlin-Independent Retrotranslocation Mechanism To Escape Proteasomal Degradation.Structural and mechanistic principles of intramembrane proteolysis--lessons from rhomboids.Specificity and regulation of the endoplasmic reticulum-associated degradation machinery.ERAD and how viruses exploit it.Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4.Intramembrane proteases as drug targets.Protein Quality Control in Health and Disease.The Interplay of Cofactor Interactions and Post-translational Modifications in the Regulation of the AAA+ ATPase p97.Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD.Protein-protein interactions indicate composition of a 480 kDa SELMA complex in the second outermost membrane of diatom complex plastids.Cytosolic extensions directly regulate a rhomboid protease by modulating substrate gating.A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP.Mutation G805R in the transmembrane domain of the LDL receptor gene causes familial hypercholesterolemia by inducing ectodomain cleavage of the LDL receptor in the endoplasmic reticulum.Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis.The AAA+ ATPase p97, a cellular multitool.
P2860
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P248
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P2860
Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins
description
2012 nî lūn-bûn
@nan
2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins
@ast
Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins
@en
Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins
@en-gb
Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins
@nl
type
label
Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins
@ast
Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins
@en
Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins
@en-gb
Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins
@nl
prefLabel
Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins
@ast
Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins
@en
Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins
@en-gb
Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins
@nl
P2093
P921
P3181
P1433
P1476
Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins
@en
P2093
Beate Geiger
Lejla Kaltak
Lina Fleig
Nina Bergbold
Priyanka Sahasrabudhe
P304
P3181
P356
10.1016/J.MOLCEL.2012.06.008
P407
P577
2012-07-12T00:00:00Z