Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death
about
Thermodynamic characterization of specific interactions between the human Lon protease and G-quartet DNACross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and DiseaseEvolution and significance of the Lon gene family in Arabidopsis organelle biogenesis and energy metabolismAnalysis of regulatory protease sequences identified through bioinformatic data mining of the Schistosoma mansoni genomeMitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disordersMitochondrial quality control in the myocardium: cooperation between protein degradation and mitophagyProteomic analysis of mitochondrial-associated ER membranes (MAM) during RNA virus infection reveals dynamic changes in protein and organelle traffickingMitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM)Biological roles of the Podospora anserina mitochondrial Lon protease and the importance of its N-domain.Live probiotic cultures and the gastrointestinal tract: symbiotic preservation of tolerance whilst attenuating pathogenicityUpregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging.The LonB protease controls membrane lipids composition and is essential for viability in the extremophilic haloarchaeon Haloferax volcanii.The PbMDJ1 gene belongs to a conserved MDJ1/LON locus in thermodimorphic pathogenic fungi and encodes a heat shock protein that localizes to both the mitochondria and cell wall of Paracoccidioides brasiliensis.Mitochondrial Lon protease at the crossroads of oxidative stress, ageing and cancer.Inhibition of Lon blocks cell proliferation, enhances chemosensitivity by promoting apoptosis and decreases cellular bioenergetics of bladder cancer: potential roles of Lon as a prognostic marker and therapeutic target in baldder cancer.Down-regulating overexpressed human Lon in cervical cancer suppresses cell proliferation and bioenergetics.Impairment of lon-induced protection against the accumulation of oxidized proteins in senescent wi-38 fibroblastsDisruption of a mitochondrial protease machinery in Plasmodium falciparum is an intrinsic signal for parasite cell death.Mitochondrial calpain 10 is degraded by Lon protease after oxidant injuryThe mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives.Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stressMatrix proteases in mitochondrial DNA function.Mitochondrial Lon regulates apoptosis through the association with Hsp60-mtHsp70 complex.Quality control of mitochondria: protection against neurodegeneration and ageing.Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain.Aging: a shift from redox regulation to oxidative damage.Functional mechanics of the ATP-dependent Lon protease- lessons from endogenous protein and synthetic peptide substrates.Overexpression of Lon contributes to survival and aggressive phenotype of cancer cells through mitochondrial complex I-mediated generation of reactive oxygen species.Mitochondrial ABC transporters function: the role of ABCB10 (ABC-me) as a novel player in cellular handling of reactive oxygen species.The role of proteolytic cellular systems in trabecular meshwork homeostasisFrom the gastrointestinal tract (GIT) to the kidneys: live bacterial cultures (probiotics) mediating reductions of uremic toxin levels via free radical signaling.The peroxisomal Lon protease LonP2 in aging and disease: functions and comparisons with mitochondrial Lon protease LonP1Molecular basis of asbestos-induced lung disease.Linkage of oxidative stress and mitochondrial dysfunctions to spontaneous culture degeneration in Aspergillus nidulans.Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging.Protein quality control in mitochondria.Mitochondrial Lon is over-expressed in high-grade gliomas, and mediates hypoxic adaptation: potential role of Lon as a therapeutic target in glioma.Roles of mitochondria in human disease.Mitochondrial stress: a bridge between mitochondrial dysfunction and metabolic diseases?Quality control of mitochondrial proteostasis.
P2860
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P2860
Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Downregulation of the human Lo ...... function and causes cell death
@ast
Downregulation of the human Lo ...... function and causes cell death
@en
Downregulation of the human Lo ...... function and causes cell death
@en-gb
Downregulation of the human Lo ...... function and causes cell death
@nl
type
label
Downregulation of the human Lo ...... function and causes cell death
@ast
Downregulation of the human Lo ...... function and causes cell death
@en
Downregulation of the human Lo ...... function and causes cell death
@en-gb
Downregulation of the human Lo ...... function and causes cell death
@nl
prefLabel
Downregulation of the human Lo ...... function and causes cell death
@ast
Downregulation of the human Lo ...... function and causes cell death
@en
Downregulation of the human Lo ...... function and causes cell death
@en-gb
Downregulation of the human Lo ...... function and causes cell death
@nl
P921
P3181
P1476
Downregulation of the human Lo ...... function and causes cell death
@en
P2093
Jenny K Ngo
Kelvin J A Davies
P304
P3181
P356
10.1016/J.FREERADBIOMED.2004.11.017
P407
P577
2005-03-01T00:00:00Z