Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure
about
Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase geneStructural homologies with ATP- and folate-binding enzymes in the crystal structure of folylpolyglutamate synthetaseAdditional organizational features of the murine folylpolyglutamate synthetase gene. Two remotely situated exons encoding an alternate 5' end and proximal open reading frame under the control of a second promoterPurification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its genePhylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymesHuman cytosolic and mitochondrial folylpolyglutamate synthetase are electrophoretically distinct. Expression in antifolate-sensitive and -resistant human cell lines.Classification of ex vivo methotrexate resistance in acute lymphoblastic and myeloid leukaemia.Mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic developmentTranscription of the human folylpoly-gamma-glutamate synthetase gene.Functional characterization of the Pneumocystis jirovecii potential drug targets dhfs and abz2 involved in folate biosynthesisA cluster of four genes encoding enzymes for five steps in the folate biosynthetic pathway of Streptococcus pneumoniae.Organization and alternate splicing of the murine folylpolyglutamate synthetase gene. Different splice variants in L1210 cells encode mitochondrial or cytosolic forms of the enzyme.Humanizing mouse folate metabolism: conversion of the dual-promoter mouse folylpolyglutamate synthetase gene to the human single-promoter structure.Clinical translation of folate receptor-targeted therapeutics.Mammalian fibroblasts lacking mitochondrial NAD+-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase are glycine auxotrophs.How to Tackle the Challenge of siRNA Delivery with Sequence-Defined Oligoamino Amides.Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase.Posttranscriptionally mediated decreases in folylpolyglutamate synthetase gene expression in some folate analogue-resistant variants of the L1210 cell. Evidence for an altered cognate mRNA in the variants affecting the rate of de novo synthesis of tRole of folylpolygutamate synthetase (FPGS) in antifolate chemotherapy; a biochemical and clinical update.Rapid decline in folylpolyglutamate synthetase activity and gene expression during maturation of HL-60 cells. Nature of the effect, impact on folate compound polyglutamate pools, and evidence for programmed down-regulation during maturation.Identification of three key active site residues in the C-terminal domain of human recombinant folylpoly-gamma-glutamate synthetase by site-directed mutagenesis.Different antifolate-resistant L1210 cell variants with either increased or decreased folylpolyglutamate synthetase gene expression at the level of mRNA transcription.Conversion of cytosolic THF to THF-polyglutamateConversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamateConversion of mitochondrial THF to THF-polyglutamateToward Eradication of B-Vitamin Deficiencies: Considerations for Crop Biofortification.
P2860
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P2860
Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure
description
1992 nî lūn-bûn
@nan
1992 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Expression cloning of a human ...... ation of its primary structure
@ast
Expression cloning of a human ...... ation of its primary structure
@en
Expression cloning of a human ...... ation of its primary structure
@en-gb
Expression cloning of a human ...... ation of its primary structure
@nl
type
label
Expression cloning of a human ...... ation of its primary structure
@ast
Expression cloning of a human ...... ation of its primary structure
@en
Expression cloning of a human ...... ation of its primary structure
@en-gb
Expression cloning of a human ...... ation of its primary structure
@nl
prefLabel
Expression cloning of a human ...... ation of its primary structure
@ast
Expression cloning of a human ...... ation of its primary structure
@en
Expression cloning of a human ...... ation of its primary structure
@en-gb
Expression cloning of a human ...... ation of its primary structure
@nl
P2093
P2860
P356
P1476
Expression cloning of a human ...... ation of its primary structure
@en
P2093
P2860
P304
P356
10.1073/PNAS.89.19.9151
P407
P577
1992-10-01T00:00:00Z