Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells
about
The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation.SAS-1 is a C2 domain protein critical for centriole integrity in C. elegansC2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals.The PLK4-STIL-SAS-6 module at the core of centriole duplicationCentriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplicationMDM1 is a microtubule-binding protein that negatively regulates centriole duplicationAn siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genesCentriolar satellite- and hMsd1/SSX2IP-dependent microtubule anchoring is critical for centriole assemblyAsterless is required for centriole length control and sperm development53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration.Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole.Centrobin-centrosomal protein 4.1-associated protein (CPAP) interaction promotes CPAP localization to the centrioles during centriole duplication.The cellular and molecular etiology of the craniofacial defects in the avian ciliopathic mutant talpid2.The centrosome and its duplication cycleCentrobin-mediated regulation of the centrosomal protein 4.1-associated protein (CPAP) level limits centriole length during elongation stageFunctional genome-wide siRNA screen identifies KIAA0586 as mutated in Joubert syndrome.How can functional annotations be derived from profiles of phenotypic annotations?Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism.A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4A yeast two-hybrid approach for probing protein-protein interactions at the centrosome.Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation.The centrosome duplication cycle in health and disease.TRIM37 promoted the growth and migration of the pancreatic cancer cells.The ubiquitin-proteasome system and chromosome 17 in cerebellar granule cells and medulloblastoma subgroups.The translational landscape of the splicing factor SRSF1 and its role in mitosis.TRIM37, a novel E3 ligase for PEX5-mediated peroxisomal matrix protein import.Maintaining centrosomes and cilia.Acquisition of Oocyte Polarity.Chemical Genetic Screen Identifies Natural Products that Modulate Centriole Number.C2CD3 binds the mother centrioleRenal findings in patients with Mulibrey nanism.Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation.Separation and Loss of Centrioles From Primordidal Germ Cells To Mature Oocytes In The Mouse
P2860
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P2860
Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells
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2013 nî lūn-bûn
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2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2013 թվականի հունիսին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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name
Discovering regulators of cent ...... tional genomics in human cells
@ast
Discovering regulators of cent ...... tional genomics in human cells
@en
Discovering regulators of cent ...... tional genomics in human cells
@en-gb
Discovering regulators of cent ...... tional genomics in human cells
@nl
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label
Discovering regulators of cent ...... tional genomics in human cells
@ast
Discovering regulators of cent ...... tional genomics in human cells
@en
Discovering regulators of cent ...... tional genomics in human cells
@en-gb
Discovering regulators of cent ...... tional genomics in human cells
@nl
prefLabel
Discovering regulators of cent ...... tional genomics in human cells
@ast
Discovering regulators of cent ...... tional genomics in human cells
@en
Discovering regulators of cent ...... tional genomics in human cells
@en-gb
Discovering regulators of cent ...... tional genomics in human cells
@nl
P921
P3181
P1433
P1476
Discovering regulators of cent ...... ional genomics in human cells.
@en
P2093
Fernando R Balestra
Petr Strnad
P304
P3181
P356
10.1016/J.DEVCEL.2013.05.016
P407
P577
2013-06-24T00:00:00Z