Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation
about
Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeresThe ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9Dynamic DNA methylation in the brain: a new epigenetic mark for experience-dependent plasticityMECP2 disorders: from the clinic to mice and backHistone regulation in the CNS: basic principles of epigenetic plasticityRole of mecp2 in experience-dependent epigenetic programmingATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndromeThe Role of ATRX in the Alternative Lengthening of Telomeres (ALT) PhenotypeRett syndrome: disruption of epigenetic control of postnatal neurological functionsATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cellsMisregulation of Alternative Splicing in a Mouse Model of Rett SyndromeCalcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activationAnalysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivoComparative analysis of the ATRX promoter and 5' regulatory region reveals conserved regulatory elements which are linked to roles in neurodevelopment, alpha-globin regulation and testicular functionBeyond Widespread Mecp2 Deletions to Model Rett Syndrome: Conditional Spatio-Temporal Knockout, Single-Point Mutations and Transgenic Rescue MiceATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neuronsA role for MeCP2 in switching gene activity via chromatin unfolding and HP1γ displacement.The chromatin remodelling factor dATRX is involved in heterochromatin formationAbnormalities of cell packing density and dendritic complexity in the MeCP2 A140V mouse model of Rett syndrome/X-linked mental retardationThe Crucial Role of DNA Methylation and MeCP2 in Neuronal FunctionUnique physical properties and interactions of the domains of methylated DNA binding protein 2.Methyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin?Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin loopingThe MeCP2/YY1 interaction regulates ANT1 expression at 4q35: novel hints for Rett syndrome pathogenesis.Transcriptional regulation of neuronal polarity and morphogenesis in the mammalian brainThe genetic basis of non-syndromic intellectual disability: a reviewEpigenetic mechanisms of depression and antidepressant actionLoss of Atrx sensitizes cells to DNA damaging agents through p53-mediated death pathwaysDirect homo- and hetero-interactions of MeCP2 and MBD2.The role of genetics in the establishment and maintenance of the epigenome.Experimental models of Rett syndrome based on Mecp2 dysfunction.DNA binding restricts the intrinsic conformational flexibility of methyl CpG binding protein 2 (MeCP2).Inactivation of X-linked tumor suppressor genes in human cancer.Roles of imprinted genes in neural stem cells.Role of ATRX in chromatin structure and function: implications for chromosome instability and human diseaseMutation of MeCP2 alters transcriptional regulation of select immediate-early genesATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease.Glaucoma related Proteomic Alterations in Human Retina SamplesMeCP2 as a genome-wide modulator: the renewal of an old story.A novel MeCP2 acetylation site regulates interaction with ATRX and HDAC1.
P2860
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P2860
Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Interaction between chromatin ...... e inherited mental retardation
@ast
Interaction between chromatin ...... e inherited mental retardation
@en
Interaction between chromatin ...... e inherited mental retardation
@en-gb
Interaction between chromatin ...... e inherited mental retardation
@nl
type
label
Interaction between chromatin ...... e inherited mental retardation
@ast
Interaction between chromatin ...... e inherited mental retardation
@en
Interaction between chromatin ...... e inherited mental retardation
@en-gb
Interaction between chromatin ...... e inherited mental retardation
@nl
prefLabel
Interaction between chromatin ...... e inherited mental retardation
@ast
Interaction between chromatin ...... e inherited mental retardation
@en
Interaction between chromatin ...... e inherited mental retardation
@en-gb
Interaction between chromatin ...... e inherited mental retardation
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
Interaction between chromatin ...... e inherited mental retardation
@en
P2093
Alan Maclean
Jamal Nasir
Jianghui Hou
Maria Jose Lafuente
Xinhua Shu
P2860
P304
P3181
P356
10.1073/PNAS.0608056104
P407
P577
2007-02-20T00:00:00Z