Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation
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Functional Evaluations of Genes Disrupted in Patients with Tourette's Disorder.Mitochondria: A Therapeutic Target for Parkinson's Disease?Deconvoluting the complexity of autophagy and Parkinson's disease for potential therapeutic purposeProgressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in miceParkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexesDrp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivoSolving the puzzle of Parkinson's disease using induced pluripotent stem cells.Inhibition of Drp1 hyper-activation is protective in animal models of experimental multiple sclerosis.Abnormalities of Mitochondrial Dynamics in Neurodegenerative Diseases.Stem cells on the brain: modeling neurodevelopmental and neurodegenerative diseases using human induced pluripotent stem cells.The mechanoenzymatic core of dynamin-related protein 1 comprises the minimal machinery required for membrane constriction.The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.Probing disorders of the nervous system using reprogramming approaches.Dynamin-related Protein 1 Oligomerization in Solution Impairs Functional Interactions with Membrane-anchored Mitochondrial Fission FactorNovel targets for mitochondrial medicine.Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTPInhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons.Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease.Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals.PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?The emergence of the mitochondrial genome as a partial regulator of nuclear function is providing new insights into the genetic mechanisms underlying age-related complex disease.Mitochondrial dynamic changes in health and genetic diseases.LRRK2 pathobiology in Parkinson's disease.Cellular processes associated with LRRK2 function and dysfunctionMolecular insight and pharmacological approaches targeting mitochondrial dynamics in skeletal muscle during obesity.Back and forth in time: Directing age in iPSC-derived lineages.LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease.Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy.Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease.LRRK2 and Autophagy.Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease.Leucine-rich repeat kinase 2 and Parkinson's disease.Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications.LRRK2 and the Immune System.Targeting LRRK2 in Parkinson's disease: an update on recent developments.Mimicking Parkinson's Disease in a Dish: Merits and Pitfalls of the Most Commonly used Dopaminergic In Vitro Models.αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson's disease.Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition.68 and FX2149 Attenuate Mutant LRRK2-R1441C-Induced Neural Transport Impairment.
P2860
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P2860
Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation
description
2013 nî lūn-bûn
@nan
2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Inhibition of excessive mitoch ...... aused by LRRK2 G2019S mutation
@ast
Inhibition of excessive mitoch ...... aused by LRRK2 G2019S mutation
@en
Inhibition of excessive mitoch ...... aused by LRRK2 G2019S mutation
@en-gb
Inhibition of excessive mitoch ...... aused by LRRK2 G2019S mutation
@nl
type
label
Inhibition of excessive mitoch ...... aused by LRRK2 G2019S mutation
@ast
Inhibition of excessive mitoch ...... aused by LRRK2 G2019S mutation
@en
Inhibition of excessive mitoch ...... aused by LRRK2 G2019S mutation
@en-gb
Inhibition of excessive mitoch ...... aused by LRRK2 G2019S mutation
@nl
prefLabel
Inhibition of excessive mitoch ...... aused by LRRK2 G2019S mutation
@ast
Inhibition of excessive mitoch ...... aused by LRRK2 G2019S mutation
@en
Inhibition of excessive mitoch ...... aused by LRRK2 G2019S mutation
@en-gb
Inhibition of excessive mitoch ...... aused by LRRK2 G2019S mutation
@nl
P2860
P3181
P356
P1476
Inhibition of excessive mitoch ...... aused by LRRK2 G2019S mutation
@en
P2093
Yu-Chin Su
P2860
P304
P3181
P356
10.1093/HMG/DDT301
P407
P50
P577
2013-06-27T00:00:00Z