Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2
about
DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegansHuman CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assemblyAn unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decayRibosome-based quality control of mRNA and nascent peptidesNonsense-mediated mRNA decay: novel mechanistic insights and biological impactThe organization and contribution of helicases to RNA splicingMechanism and regulation of the nonsense-mediated decay pathwayThe dharma of nonsense-mediated mRNA decay in mammalian cellsThe RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.The Ighmbp2 helicase structure reveals the molecular basis for disease-causing mutations in DMSA1Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicasePhospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5–SMG7 and SMG6A bacterial-like mechanism for transcription termination by the Sen1p helicase in budding yeast.Cofactor-dependent specificity of a DEAD-box protein.Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit.Saccharomyces cerevisiae Sen1 Helicase Domain Exhibits 5'- to 3'-Helicase Activity with a Preference for Translocation on DNA Rather than RNANonsense-mediated mRNA decay in humans at a glanceNonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StoryOrganizing principles of mammalian nonsense-mediated mRNA decayIn Silico Analysis of the Structural and Biochemical Features of the NMD Factor UPF1 in Ustilago maydisHIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA.Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activitiesBiochemical characterization of the helicase Sen1 provides new insights into the mechanisms of non-coding transcription termination.Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase familyCrystal structure of Middle East respiratory syndrome coronavirus helicase.Nonsense-mediated decay factors are involved in the regulation of selenoprotein mRNA levels during selenium deficiencyA novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD.Cell type-dependent gene regulation by Staufen2 in conjunction with Upf1.Saccharomyces cerevisiae Sen1 as a model for the study of mutations in human Senataxin that elicit cerebellar ataxia.A post-translational regulatory switch on UPF1 controls targeted mRNA degradationEmerging roles for ribonucleoprotein modification and remodeling in controlling RNA fateUPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome.RNA helicase A activity is inhibited by oncogenic transcription factor EWS-FLI1.Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question.Structural basis for regulation of RNA-binding proteins by phosphorylation.Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics.Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation.A highly conserved region essential for NMD in the Upf2 N-terminal domainNMD: At the crossroads between translation termination and ribosome recycling.
P2860
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P2860
Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Molecular mechanisms for the R ...... pf1 and its regulation by Upf2
@ast
Molecular mechanisms for the R ...... pf1 and its regulation by Upf2
@en
Molecular mechanisms for the R ...... pf1 and its regulation by Upf2
@en-gb
Molecular mechanisms for the R ...... pf1 and its regulation by Upf2
@nl
type
label
Molecular mechanisms for the R ...... pf1 and its regulation by Upf2
@ast
Molecular mechanisms for the R ...... pf1 and its regulation by Upf2
@en
Molecular mechanisms for the R ...... pf1 and its regulation by Upf2
@en-gb
Molecular mechanisms for the R ...... pf1 and its regulation by Upf2
@nl
prefLabel
Molecular mechanisms for the R ...... pf1 and its regulation by Upf2
@ast
Molecular mechanisms for the R ...... pf1 and its regulation by Upf2
@en
Molecular mechanisms for the R ...... pf1 and its regulation by Upf2
@en-gb
Molecular mechanisms for the R ...... pf1 and its regulation by Upf2
@nl
P2093
P50
P1433
P1476
Molecular mechanisms for the R ...... pf1 and its regulation by Upf2
@en
P2093
Francesca Fiorini
Hervé Le Hir
Sutapa Chakrabarti
Uma Jayachandran
P304
P356
10.1016/J.MOLCEL.2011.02.010
P407
P577
2011-03-18T00:00:00Z