The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin
about
A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit countingImpact of heme on specific antibody production in mice: promotive, inhibitive or null outcome is determined by its concentration.Deformability in the cleavage site of primary microRNA is not sensed by the double-stranded RNA binding domains in the microprocessor component DGCR8The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage.Splicing remodels the let-7 primary microRNA to facilitate Drosha processing in Caenorhabditis elegans.Cobalt(III) Protoporphyrin Activates the DGCR8 Protein and Can Compensate microRNA Processing Deficiency.Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer.Post-transcriptional modulation of protein phosphatase PPP2CA and tumor suppressor PTEN by endogenous siRNA cleaved from hairpin within PTEN mRNA 3'UTR in human liver cells.Design of Effective Primary MicroRNA Mimics With Different Basal Stem Conformations.Regulation of heme biosynthesis and transport in metazoa.A Role of MicroRNAs in Cell Differentiation During Gonad Development.CO and NO bind to Fe(II) DiGeorge critical region 8 heme but do not restore primary microRNA processing activity.ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner.Stress-induced changes in miRNA biogenesis and functioning.EnABLing microprocessor for apoptosis.Microprocessor Recruitment to Elongating RNA Polymerase II Is Required for Differential Expression of MicroRNAs.Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs.Microprocessor depends on hemin to recognize the apical loop of primary microRNA.The RNA helicase DDX17 controls the transcriptional activity of REST and the expression of proneural microRNAs in neuronal differentiation
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P2860
The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
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2014年论文
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name
The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin
@ast
The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin
@en
The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin
@nl
type
label
The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin
@ast
The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin
@en
The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin
@nl
prefLabel
The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin
@ast
The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin
@en
The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin
@nl
P2093
P2860
P921
P3181
P1433
P1476
The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin
@en
P2093
Grant Shoffner
Jen Quick-Cleveland
Jose P Jacob
Rachel Senturia
Sara H Weitz
P2860
P304
P3181
P356
10.1016/J.CELREP.2014.05.013
P407
P577
2014-06-26T00:00:00Z