Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics
about
Relative tissue expression of homologous torsinB correlates with the neuronal specific importance of DYT1 dystonia-associated torsinACSN complex controls the stability of selected synaptic proteins via a torsinA-dependent processLULL1 retargets TorsinA to the nuclear envelope revealing an activity that is impaired by the DYT1 dystonia mutationTorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeletonPrintor, a novel torsinA-interacting protein implicated in dystonia pathogenesisMutations in the autoregulatory domain of β-tubulin 4a cause hereditary dystoniaCerebellothalamocortical connectivity regulates penetrance in dystoniaTorsins: not your typical AAA+ ATPasesDystonia-associated mutations cause premature degradation of torsinA protein and cell-type-specific mislocalization to the nuclear envelopeAbnormal structure-function relationships in hereditary dystonia.The BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia.Cell-autonomous alteration of dopaminergic transmission by wild type and mutant (DeltaE) TorsinA in transgenic mice.Mutant torsinA interacts with tyrosine hydroxylase in cultured cells.Lamin-binding ProteinsAltered dendritic morphology of Purkinje cells in Dyt1 ΔGAG knock-in and purkinje cell-specific Dyt1 conditional knockout mice.Biochemical and cellular analysis of human variants of the DYT1 dystonia protein, TorsinA/TOR1AThe early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response.Current Gaps in the Understanding of the Subcellular Distribution of Exogenous and Endogenous Protein TorsinA.A unique redox-sensing sensor II motif in TorsinA plays a critical role in nucleotide and partner binding.The zebrafish homologue of the human DYT1 dystonia gene is widely expressed in CNS neurons but non-essential for early motor system development4-Phenylbutyrate attenuates the ER stress response and cyclic AMP accumulation in DYT1 dystonia cell models.Evaluation of TorsinA as a target for Parkinson disease therapy in mouse modelsMutant torsinA interferes with protein processing through the secretory pathway in DYT1 dystonia cells.Untethering the nuclear envelope and cytoskeleton: biologically distinct dystonias arising from a common cellular dysfunctionIncreased cerebellar activation during sequence learning in DYT1 carriers: an equiperformance studyGenetic and clinical features of primary torsion dystonia.Torsin A Localization in the Mouse Cerebellar Synaptic Circuitry.Abnormal striatal and thalamic dopamine neurotransmission: Genotype-related features of dystonia.The pathogenic human Torsin A in Drosophila activates the unfolded protein response and increases susceptibility to oxidative stress.Motor deficits and hyperactivity in Dyt1 knockdown mice.Functional imaging in hereditary dystonia.TorsinA participates in endoplasmic reticulum-associated degradationExperimental therapeutics for dystonia.Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions.Identifying the genetic components underlying the pathophysiology of movement disorders.The genetics of dystonias.Glial elements contribute to stress-induced torsinA expression in the CNS and peripheral nervous systemSubtle microstructural changes of the cerebellum in a knock-in mouse model of DYT1 dystoniaDystonia as a network disorder: what is the role of the cerebellum?Primary dystonia: molecules and mechanisms.
P2860
Q22001542-1D778282-8878-417B-94AA-FB3F33AD9B1AQ24307876-BFE351D2-9413-47DF-936A-07C18CDE96C7Q24311570-2A80C4B1-21FF-4B63-9F35-871A3FE97DD0Q24317502-9CF0F1D6-92ED-4618-9AE5-6332107A19DDQ24338612-A1A589B4-A880-49EE-9885-D57BC1C077DEQ24605412-D2AE7E12-0F57-475A-8D6A-1E472BCDA52BQ24652781-915090E5-2AC3-4FF4-92C2-F75F41F80B0DQ28087663-E0CCBBBA-DE86-4BD3-A93E-1B6BA3BD161CQ28386148-3BEA5FC1-B8DB-436B-9DC3-4A7644E498A8Q33402008-0C6753C2-F87D-4492-AD26-61D6BA7EB92AQ33556224-5F6E173B-50FA-4792-A532-F2F54D949B9BQ33723034-0F163E5D-9DB9-4A8D-A280-FB2AC32C2D8EQ33750936-7A6447AB-5EDF-49A9-BAA9-D164DF542C08Q33752204-58E8790D-57A4-4401-A3DB-B046EC3C3236Q33867544-6A151CA2-7AEF-4472-9DEF-A443BFBCF3D1Q34052884-6E9B9824-C5FB-4A1A-9305-BE27E7024626Q34083670-5A3073D2-0174-40E0-B468-B9C64062D912Q34245374-AE4E43FC-6AF1-4783-849B-9D765D22A289Q34333556-E1820F27-A84D-4F8F-A959-888F27C432C9Q34428283-451A1E83-04BB-4633-9F31-6E836E9B473AQ34472800-B6E42FDF-0AC8-44A4-BC9F-4C13EFCA02C1Q34490978-EB1CEE8C-8633-428F-9FBE-B8261254DABBQ34578567-E01B1600-56BB-4114-A759-B01A985D4270Q34638417-C894F9FC-6839-4C12-91E8-89AE6EEE02E4Q34703465-EF331A09-C194-4B95-98FE-2B6D46697DE4Q34777884-54A0BBC3-3EE3-4D2F-893D-0C72D24E7FC8Q34808401-014E8333-63AC-465B-9EF7-46D42DF22325Q34986983-346E321A-3299-4664-A2B6-EA29D32DF1CBQ35555819-BCD7B361-00D6-46DD-92CC-EE2C66B124EBQ35629540-AECAF8A2-6ADB-4D8F-80AF-7143AE69C3F4Q36276626-67D7B8D5-D5FD-4368-B0B3-AA9B438BFE93Q36487761-CA6A804A-DA0B-4A31-9C87-C7E1879DC876Q36569704-5A2C398D-87CA-456A-AA5E-ED07727447B8Q36858688-144543E5-56B1-43FA-A01B-D85C54A1D177Q36925207-1E3E2CCB-A20A-45C1-8E6F-26ADD5E80573Q36934972-3A27C834-5826-4819-BB14-8C624960792AQ37001321-10E91326-F6DB-43FA-AF0D-F48D6F71EAB1Q37424519-71D5B06B-1572-4E6D-A238-1C53AC2B3A8BQ37592345-77718D40-44D2-45AF-92C9-813FF9F21583Q37614200-C192B875-8B14-4E23-9725-1DF91F5D98D8
P2860
Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Dystonia-causing mutant torsin ...... nce with cytoskeletal dynamics
@ast
Dystonia-causing mutant torsin ...... nce with cytoskeletal dynamics
@en
Dystonia-causing mutant torsin ...... nce with cytoskeletal dynamics
@nl
type
label
Dystonia-causing mutant torsin ...... nce with cytoskeletal dynamics
@ast
Dystonia-causing mutant torsin ...... nce with cytoskeletal dynamics
@en
Dystonia-causing mutant torsin ...... nce with cytoskeletal dynamics
@nl
prefLabel
Dystonia-causing mutant torsin ...... nce with cytoskeletal dynamics
@ast
Dystonia-causing mutant torsin ...... nce with cytoskeletal dynamics
@en
Dystonia-causing mutant torsin ...... nce with cytoskeletal dynamics
@nl
P2093
P921
P1476
Dystonia-causing mutant torsin ...... nce with cytoskeletal dynamics
@en
P2093
Brian P Niland
D Cristopher Bragg
Jeffrey W Hewett
Xandra O Breakefield
P304
P356
10.1016/J.NBD.2005.10.012
P407
P577
2006-04-01T00:00:00Z