Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression
about
Chemico-genetic strategies to inhibit the leukemic potential of threonine aspartase-1Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expressionAutoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathwayNew insight into the molecular mechanisms of MLL-associated leukemiaUncleaved TFIIA is a substrate for taspase 1 and active in transcriptionTaspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosismiR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with miR-221Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer PathwaysRevisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemiaAsparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis)Hijacked in cancer: the KMT2 (MLL) family of methyltransferasesCrystallographic Snapshot of a Productive Glycosylasparaginase–Substrate ComplexStructural constraints on autoprocessing of the human nucleoporin Nup98Free Glycine Accelerates the Autoproteolytic Activation of Human AsparaginaseCARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domainBioassays to monitor Taspase1 function for the identification of pharmacogenetic inhibitorsOverexpression of the catalytically impaired Taspase1 T234V or Taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cellsHistone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll.Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiationCleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programsDisordered epigenetic regulation in MLL-related leukemia.Genome-wide analysis of regulatory proteases sequences identified through bioinformatics data mining in Taenia solium.Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryosPolycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescenceAlternative epigenetic chromatin states of polycomb target genesOn the use of resampling tests for evaluating statistical significance of binding-site co-occurrence.Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.Molecular genetic analyses of polytene chromosome region 72A-D in Drosophila melanogaster reveal a gene desert in 72DA pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growthThe N-end rule pathway and regulation by proteolysisTrithorax group proteins: switching genes on and keeping them active.Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis.The molecular mechanics of mixed lineage leukemia.Polycomb preferentially targets stalled promoters of coding and noncoding transcriptsProteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.Histone methylases MLL1 and MLL3 coordinate with estrogen receptors in estrogen-mediated HOXB9 expression.MLL becomes functional through intra-molecular interaction not by proteolytic processingMll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations.Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways.
P2860
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P2860
Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Taspase1: a threonine aspartas ...... and proper HOX gene expression
@ast
Taspase1: a threonine aspartas ...... and proper HOX gene expression
@en
Taspase1: a threonine aspartas ...... and proper HOX gene expression
@en-gb
Taspase1: a threonine aspartas ...... and proper HOX gene expression
@nl
type
label
Taspase1: a threonine aspartas ...... and proper HOX gene expression
@ast
Taspase1: a threonine aspartas ...... and proper HOX gene expression
@en
Taspase1: a threonine aspartas ...... and proper HOX gene expression
@en-gb
Taspase1: a threonine aspartas ...... and proper HOX gene expression
@nl
prefLabel
Taspase1: a threonine aspartas ...... and proper HOX gene expression
@ast
Taspase1: a threonine aspartas ...... and proper HOX gene expression
@en
Taspase1: a threonine aspartas ...... and proper HOX gene expression
@en-gb
Taspase1: a threonine aspartas ...... and proper HOX gene expression
@nl
P2093
P3181
P1433
P1476
Taspase1: a threonine aspartas ...... and proper HOX gene expression
@en
P2093
Emily H-Y Cheng
James J-D Hsieh
Stanley J Korsmeyer
P304
P3181
P356
10.1016/S0092-8674(03)00816-X
P407
P577
2003-10-31T00:00:00Z