Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system

Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system

Item
http://www.wikidata.org/entity/Q24300528
Prediction of the coupling specificity of GPCRs to four families of G-proteins using hidden Markov models and artificial neural networks.The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site.Transcriptomic-anatomic analysis of the mouse habenula uncovers a high molecular heterogeneity among neurons in the lateral complex, while gene expression in the medial complex largely obeys subnuclear boundaries.GPR142 Agonists Stimulate Glucose-Dependent Insulin Secretion via Gq-Dependent SignalingGPR142 Controls Tryptophan-Induced Insulin and Incretin Hormone Secretion to Improve Glucose MetabolismDiscovery and pharmacological effects of a novel GPR142 antagonist.High-throughput screening of antagonists for the orphan G-protein coupled receptor GPR139P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion.Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139.Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139.The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP(+) and Rotenone Toxicity.Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor.Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro.Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats.
P2860

Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system

Item
http://www.wikidata.org/entity/Q24300528
description
2005 nî lūn-bûn
@nan
2005 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մայիսին հրատարակված գիտական հոդված
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2005年の論文
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2005年論文
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2005年論文
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2005年論文
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2005年論文
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2005年論文
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2005年论文
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name
Molecular cloning and characte ...... in the central nervous system
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Molecular cloning and characte ...... in the central nervous system
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Molecular cloning and characte ...... in the central nervous system
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Molecular cloning and characte ...... in the central nervous system
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type
label
Molecular cloning and characte ...... in the central nervous system
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Molecular cloning and characte ...... in the central nervous system
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Molecular cloning and characte ...... in the central nervous system
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Molecular cloning and characte ...... in the central nervous system
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Molecular cloning and characte ...... in the central nervous system
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Molecular cloning and characte ...... in the central nervous system
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Molecular cloning and characte ...... in the central nervous system
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Molecular cloning and characte ...... in the central nervous system
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Molecular cloning and characte ...... in the central nervous system
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10.1016/J.BBRC.2005.03.174
P407
P433
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P698
P921