Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7
about
Fbxw7 Tumor Suppressor: A Vital Regulator Contributes to Human TumorigenesisΓ-secretase components as predictors of breast cancer outcomePresenilin/gamma-Secretase and Inflammation.Loss of presenilin 2 is associated with increased iPLA2 activity and lung tumor development.Emerging roles of the FBW7 tumour suppressor in stem cell differentiation.Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms.The two faces of FBW7 in cancer drug resistance.Tumor suppressor functions of FBW7 in cancer development and progression.Interaction of EGFR to δ-catenin leads to δ-catenin phosphorylation and enhances EGFR signaling.Guttiferone K impedes cell cycle re-entry of quiescent prostate cancer cells via stabilization of FBXW7 and subsequent c-MYC degradationStudy of single nucleotide polymorphisms of FBW7 and its substrate genes revealed a predictive factor for paclitaxel plus cisplatin chemotherapy in Chinese patients with advanced esophageal squamous cell carcinoma.Distinct Interactions of EBP1 Isoforms with FBXW7 Elicits Different Functions in Cancer.Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines.The stability of Fbw7α in M-phase requires its phosphorylation by PKC.Differential regulation of FBXW7 isoforms by various stress stimuli.Presenilin Mutation Suppresses Lung Tumorigenesis via Inhibition of Peroxiredoxin 6 Activity and Expression.Regulated intramembrane proteolysis: emergent role in cell signalling pathways.δ-Catenin Increases the Stability of EGFR by Decreasing c-Cbl Interaction and Enhances EGFR/Erk1/2 Signaling in Prostate Cancer.F-box proteins involved in cancer-associated drug resistance.FBXW7: a critical tumor suppressor of human cancers
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Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Presenilin modulates EGFR sign ...... ting the ubiquitin ligase Fbw7
@ast
Presenilin modulates EGFR sign ...... ting the ubiquitin ligase Fbw7
@en
Presenilin modulates EGFR sign ...... ting the ubiquitin ligase Fbw7
@en-gb
Presenilin modulates EGFR sign ...... ting the ubiquitin ligase Fbw7
@nl
type
label
Presenilin modulates EGFR sign ...... ting the ubiquitin ligase Fbw7
@ast
Presenilin modulates EGFR sign ...... ting the ubiquitin ligase Fbw7
@en
Presenilin modulates EGFR sign ...... ting the ubiquitin ligase Fbw7
@en-gb
Presenilin modulates EGFR sign ...... ting the ubiquitin ligase Fbw7
@nl
prefLabel
Presenilin modulates EGFR sign ...... ting the ubiquitin ligase Fbw7
@ast
Presenilin modulates EGFR sign ...... ting the ubiquitin ligase Fbw7
@en
Presenilin modulates EGFR sign ...... ting the ubiquitin ligase Fbw7
@en-gb
Presenilin modulates EGFR sign ...... ting the ubiquitin ligase Fbw7
@nl
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Presenilin modulates EGFR sign ...... ting the ubiquitin ligase Fbw7
@en
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P2860
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P3181
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10.1038/ONC.2010.57
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2010-03-08T00:00:00Z
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1027702125