Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets
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TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cellsGenetics of Insulin Resistance and the Metabolic SyndromeNovel phenotypes of prediabetes?Pharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agentsDissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing toolsDoes disruption of circadian rhythms contribute to beta-cell failure in type 2 diabetes?TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liverTCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention programPharmacogenomics in type 2 diabetes: oral antidiabetic drugs.Pharmacogenomics of Drug Response in Type 2 Diabetes: Toward the Definition of Tailored Therapies?Importance of β-Catenin in glucose and energy homeostasis.Association of genetic variants with isolated fasting hyperglycaemia and isolated postprandial hyperglycaemia in a Han Chinese population.Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies.Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors.Puerarin Protects Pancreatic β-Cells in Obese Diabetic Mice via Activation of GLP-1R SignalingGenotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humansClinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146.An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cellsInfluence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin.Association of the type 2 diabetes mellitus susceptibility gene, TCF7L2, with schizophrenia in an Arab-Israeli family sampleCOUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathwaysExpression of the diabetes-associated gene TCF7L2 in adult mouse brainTCF7L2 is a master regulator of insulin production and processing.Carriers of a novel frame-shift insertion in WNT16a possess elevated pancreatic expression of TCF7L2.The emerging genetic architecture of type 2 diabetesThe search for genetic risk factors of type 2 diabetes mellitus.Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis.Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism.Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in micePredicting diabetes: our relentless quest for genomic nuggets.Association of TCF7L2 Genetic Polymorphisms with Type 2 Diabetes Mellitus in the Uygur Population of China.Associations of common genetic variants with age-related changes in fasting and postload glucose: evidence from 18 years of follow-up of the Whitehall II cohortAssociation of the Genetic Polymorphisms in Transcription Factor 7-Like 2 and Peroxisome Proliferator-Activated Receptors- γ 2 with Type 2 Diabetes Mellitus and is Interaction with Obesity Status in Emirati PopulationReduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes.The role of the Wnt signaling pathway in incretin hormone production and function.Review of the neuroanatomic landscape implicated in glucose sensing and regulation of nutrient signaling: immunophenotypic localization of diabetes gene Tcf7l2 in the developing murine brain.The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspectiveGeniposide promotes beta-cell regeneration and survival through regulating β-catenin/TCF7L2 pathwayDiabetes and obesity-related genes and the risk of neural tube defects in the national birth defects prevention study.
P2860
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P2860
Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
Transcription factor 7-like 2 ...... ion in human pancreatic islets
@ast
Transcription factor 7-like 2 ...... ion in human pancreatic islets
@en
Transcription factor 7-like 2 ...... ion in human pancreatic islets
@en-gb
Transcription factor 7-like 2 ...... ion in human pancreatic islets
@nl
type
label
Transcription factor 7-like 2 ...... ion in human pancreatic islets
@ast
Transcription factor 7-like 2 ...... ion in human pancreatic islets
@en
Transcription factor 7-like 2 ...... ion in human pancreatic islets
@en-gb
Transcription factor 7-like 2 ...... ion in human pancreatic islets
@nl
prefLabel
Transcription factor 7-like 2 ...... ion in human pancreatic islets
@ast
Transcription factor 7-like 2 ...... ion in human pancreatic islets
@en
Transcription factor 7-like 2 ...... ion in human pancreatic islets
@en-gb
Transcription factor 7-like 2 ...... ion in human pancreatic islets
@nl
P2093
P3181
P356
P1433
P1476
Transcription factor 7-like 2 ...... ion in human pancreatic islets
@en
P2093
Aleksey V Matveyenko
Fabienne T Schulthess
José Oberholzer
Kathrin Maedler
Nadine S Sauter
P304
P356
10.2337/DB07-0847
P407
P577
2008-03-01T00:00:00Z