Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
about
The UBIAD1 prenyltransferase links menaquinone-4 [corrected] synthesis to cholesterol metabolic enzymesUbiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesisCytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11Vitamin K and hepatocellular carcinoma: The basic and clinicVitamin K₂ therapy for postmenopausal osteoporosisStructural Insights into Ubiquinone Biosynthesis in MembranesStructure of a membrane-embedded prenyltransferase homologous to UBIAD1Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1Structural basis for catalysis at the membrane-water interface.UBIAD1-mediated vitamin K2 synthesis is required for vascular endothelial cell survival and development.Tissue Concentrations of Vitamin K and Expression of Key Enzymes of Vitamin K Metabolism Are Influenced by Sex and Diet but Not Housing in C57Bl6 Mice.Methods for Structural and Functional Analyses of Intramembrane Prenyltransferases in the UbiA Superfamily.Plasma phylloquinone, menaquinone-4 and menaquinone-7 levels and coronary artery calcificationVitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of miceThe bladder tumor suppressor protein TERE1 (UBIAD1) modulates cell cholesterol: implications for tumor progression.Deuterium-labeled phylloquinone fed to α-tocopherol-injected rats demonstrates sensitivity of low phylloquinone-containing tissues to menaquinone-4 depletionMenatetrenone for the treatment of osteoporosis.Identification of a hotdog fold thioesterase involved in the biosynthesis of menaquinone in Escherichia coli.Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women.A novel Golgi retention signal RPWS for tumor suppressor UBIAD1.Liver-specific γ-glutamyl carboxylase-deficient mice display bleeding diathesis and short life span.The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductaseA mutation in the UBIAD1 gene in a Han Chinese family with Schnyder corneal dystrophyDifferential Effects of Dabigatran and Warfarin on Bone Volume and Structure in Rats with Normal Renal FunctionDeuterium-labeled phylloquinone has tissue-specific conversion to menaquinone-4 among Fischer 344 male ratsVitamin K supplementation does not prevent bone loss in ovariectomized Norway rats.Role of UBIAD1 in Intracellular Cholesterol Metabolism and Vascular Cell Calcification.A high-throughput screening strategy for accurate quantification of menaquinone based on fluorescence-activated cell sorting.Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways.Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesisMechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agentsStructure-activity relationship study of vitamin k derivatives yields highly potent neuroprotective agentsVitamin K nutrition, metabolism, and requirements: current concepts and future research.Bringing Bioactive Compounds into Membranes: The UbiA Superfamily of Intramembrane Aromatic Prenyltransferases.Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and GolgiMechanisms for the prevention of vitamin E excessThe tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes.Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats.Recent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesis.Menaquinones, bacteria, and the food supply: the relevance of dairy and fermented food products to vitamin K requirements.
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P2860
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
@ast
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
@en
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
@en-gb
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
@nl
type
label
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
@ast
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
@en
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
@en-gb
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
@nl
prefLabel
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
@ast
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
@en
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
@en-gb
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
@nl
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P3181
P356
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Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
@en
P2093
Kimie Nakagawa
Masato Watanabe
Naohito Yuge
Naoko Okuda
Natsumi Sawada
Toshio Okano
Yoshihisa Hirota
Yoshitomo Suhara
Yuka Shimomura
Yuri Uchino
P2860
P2888
P304
P3181
P356
10.1038/NATURE09464
P407
P577
2010-11-04T00:00:00Z
P5875
P6179
1035441604