IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
about
Cyclic cytidine 3',5'-monophosphate (cCMP) signals via cGMP kinase I.cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.InsP3R-associated cGMP kinase substrate determines inositol 1,4,5-trisphosphate receptor susceptibility to phosphoregulation by cyclic nucleotide-dependent kinasesPhosphoproteomic analysis of platelets activated by pro-thrombotic oxidized phospholipids and thrombin.Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.Functional osteoclast attachment requires inositol-1,4,5-trisphosphate receptor-associated cGMP-dependent kinase substrate.The genetics of common variation affecting platelet development, function and pharmaceutical targeting.Effect of storage on levels of nitric oxide metabolites in platelet preparationsComplicated atheromatous plaque as integral atherogenesisStructures of cGMP-Dependent Protein Kinase (PKG) Iα Leucine Zippers Reveal an Interchain Disulfide Bond Important for Dimer Stability.Compartmentation and compartment-specific regulation of PDE5 by protein kinase G allows selective cGMP-mediated regulation of platelet functionsRelaxin, its receptor (RXFP1), and insulin-like peptide 4 expression through gestation and in placenta accreta.Chlorin e6 Prevents ADP-Induced Platelet Aggregation by Decreasing PI3K-Akt Phosphorylation and Promoting cAMP Production.Blockade of the purinergic P2Y12 receptor greatly increases the platelet inhibitory actions of nitric oxide.Ion channel regulation of intracellular calcium and airway smooth muscle function.Nitric oxide production pathways in erythrocytes and plasma.Antiplatelet activity of nifedipine is mediated by inhibition of NF-κB activation caused by enhancement of PPAR-β/-γ activity.Nitric oxide at a glance.Novel roles of cAMP/cGMP-dependent signaling in platelets.The unique contribution of ion channels to platelet and megakaryocyte function.Cyclic nucleotide phosphodiesterases (PDEs): coincidence detectors acting to spatially and temporally integrate cyclic nucleotide and non-cyclic nucleotide signals.The role of cGMP and its signaling pathways in kidney disease.Cyclic nucleotide dependent dephosphorylation of regulator of G-protein signaling 18 in human platelets.Inositol 1,4,5-triphosphate-associated cGMP kinase substrate: Basis Sequence: Mouse.Platelet Ca(2+) responses coupled to glycoprotein VI and Toll-like receptors persist in the presence of endothelial-derived inhibitors: roles for secondary activation of P2X1 receptors and release from intracellular Ca(2+) storesTargeting aspirin resistance with nutraceuticals: a possible strategy for reducing cardiovascular morbidity and mortality.IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation.Elevated plasma concentration of NO and cGMP may be responsible for the decreased platelet aggregation and platelet leukocyte conjugation in platelets hypo-responsive to catecholamines.Dermal application of nitric oxide in vivo: kinetics, biological responses, and therapeutic potential in humans.Transport limitations of nitric oxide inhibition of platelet aggregation under flow.Cyclic Guanosine Monophosphate-Dependent Protein Kinase I Stimulators and Activators Are Therapeutic Alternatives for Sickle Cell Disease.Differential eNOS-signalling by platelet subpopulations regulates adhesion and aggregation.Negative regulators of platelet activation and adhesion.PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ releaseReversal of stress fibre formation by Nitric Oxide mediated RhoA inhibition leads to reduction in the height of preformed thrombi.Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change.An N-terminally truncated form of cyclic GMP-dependent protein kinase Iα (PKG Iα) is monomeric, autoinhibited, and provides a model for activation.Collagen stimulation of platelets induces a rapid spatial response of cAMP and cGMP signaling scaffolds.Signaling via IRAG is essential for NO/cGMP-dependent inhibition of platelet activation.
P2860
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P2860
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
@ast
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
@en
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
@en-gb
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
@nl
type
label
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
@ast
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
@en
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
@en-gb
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
@nl
prefLabel
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
@ast
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
@en
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
@en-gb
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
@nl
P2093
P1433
P1476
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
@en
P2093
Christina Eiglsperger
Franz Hofmann
Ildiko Konrad
Marie-Luise von Brühl
Matthias Werner
Melanie Antl
Steffen Massberg
Thomas Kocher
P356
10.1182/BLOOD-2005-10-026294
P407
P577
2007-01-15T00:00:00Z