LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth
about
Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of ParkinsonismThe Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activityA direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylationLRRK2 phosphorylates novel tau epitopes and promotes tauopathyLeucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3βCurrent understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor designMicrotubule-stabilizing agents as potential therapeutics for neurodegenerative diseaseThe regulation and deregulation of Wnt signaling by PARK genes in health and diseaseHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsThe role of the LRRK2 gene in ParkinsonismPhosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPasesAlpha-synuclein and tau: teammates in neurodegeneration?A visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology.ERKed by LRRK2: a cell biological perspective on hereditary and sporadic Parkinson's disease.Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model.Mechanisms of Parkinson's disease-related proteins in mediating secondary brain damage after cerebral ischemia.Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease.LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization.Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase ActivityCognitive Impairments in LRRK2-Related Parkinson's Disease: A Study in Chinese Individuals.Evolution of neurodegeneration.Cellular effects of LRRK2 mutations.Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation.Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.LRRK2: an éminence grise of Wnt-mediated neurogenesis?Back to the tubule: microtubule dynamics in Parkinson's disease.Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models.LRRK2 and vesicle trafficking.Targeting leucine-rich repeat kinase 2 in Parkinson's disease.LRRK2 and neuroinflammation: partners in crime in Parkinson's disease?Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation.LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesisFunction and dysfunction of leucine-rich repeat kinase 2 (LRRK2): Parkinson's disease and beyondCellular processes associated with LRRK2 function and dysfunctionThe Role of α-Synuclein and LRRK2 in Tau Phosphorylation.LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease.I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway.Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs.LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein.
P2860
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P2860
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
LRRK2 phosphorylates tubulin-a ...... ociation and neurite outgrowth
@ast
LRRK2 phosphorylates tubulin-a ...... ociation and neurite outgrowth
@en
LRRK2 phosphorylates tubulin-a ...... ociation and neurite outgrowth
@en-gb
LRRK2 phosphorylates tubulin-a ...... ociation and neurite outgrowth
@nl
type
label
LRRK2 phosphorylates tubulin-a ...... ociation and neurite outgrowth
@ast
LRRK2 phosphorylates tubulin-a ...... ociation and neurite outgrowth
@en
LRRK2 phosphorylates tubulin-a ...... ociation and neurite outgrowth
@en-gb
LRRK2 phosphorylates tubulin-a ...... ociation and neurite outgrowth
@nl
prefLabel
LRRK2 phosphorylates tubulin-a ...... ociation and neurite outgrowth
@ast
LRRK2 phosphorylates tubulin-a ...... ociation and neurite outgrowth
@en
LRRK2 phosphorylates tubulin-a ...... ociation and neurite outgrowth
@en-gb
LRRK2 phosphorylates tubulin-a ...... ociation and neurite outgrowth
@nl
P2093
P2860
P3181
P1433
P1476
LRRK2 phosphorylates tubulin-a ...... ociation and neurite outgrowth
@en
P2093
Etsuro Ohta
Fumitaka Kawakami
Fumiya Obata
Hiroko Maruyama
Minori Suzuki
Naoki Shimada
Takafumi Ichikawa
Takatoshi Yabata
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0030834
P407
P577
2012-01-01T00:00:00Z