Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter
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The human proton-coupled folate transporter (hPCFT): modulation of intestinal expression and function by drugsBiology of the major facilitative folate transporters SLC19A1 and SLC46A1Functional characterization of PCFT/HCP1 as the molecular entity of the carrier-mediated intestinal folate transport system in the rat modelSubstituted cysteine accessibility reveals a novel transmembrane 2-3 reentrant loop and functional role for transmembrane domain 2 in the human proton-coupled folate transporter.The Concise Guide to PHARMACOLOGY 2013/14: transporters.Molecular and biochemical characterization of folate transport proteins in retinal Müller cellsHeme and non-heme iron transporters in non-polarized and polarized cells.The proton-coupled folate transporter: physiological and pharmacological roles.The pharmacokinetics and pharmacodynamics of iron preparations.Functional characteristics of the human ortholog of riboflavin transporter 2 and riboflavin-responsive expression of its rat ortholog in the small intestine indicate its involvement in riboflavin absorption.Mechanisms of membrane transport of folates into cells and across epithelia.Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporterIdentification and functional impact of homo-oligomers of the human proton-coupled folate transporter.The human proton-coupled folate transporter: Biology and therapeutic applications to cancer.Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors.Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors.The intestinal absorption of folates.Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues.Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell typesN-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT).Subcellular localization and distribution of the reduced folate carrier in normal rat tissuesThe physiological role of drug transporters.Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1)Evaluation of folate receptor 1 (FOLR1) mRNA expression, its specific promoter methylation and global DNA hypomethylation in type I and type II ovarian cancers.Intestinal transport of aminopterin enantiomers in dogs and humans with psoriasis is stereoselective: evidence for a mechanism involving the proton-coupled folate transporter.Expression in Sf9 insect cells, purification and functional reconstitution of the human proton-coupled folate transporter (PCFT, SLC46A1).Inhibition of the proton-coupled folate transporter (PCFT-SLC46A1) by bicarbonate and other anions.Involvement of Multiple Transporters-mediated Transports in Mizoribine and Methotrexate Pharmacokinetics.Mechanism and regulation of folate uptake by pancreatic acinar cells: effect of chronic alcohol consumption.A general map of iron metabolism and tissue-specific subnetworks.Functional and mechanistic roles of the human proton-coupled folate transporter transmembrane domain 6-7 linker.Drug interaction between methotrexate and salazosulfapyridine in Japanese patients with rheumatoid arthritis.The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption.Identification and functional characterization of the first nucleobase transporter in mammals: implication in the species difference in the intestinal absorption mechanism of nucleobases and their analogs between higher primates and other mammalsThe effect of oxidative stress upon the intestinal uptake of folic acid: in vitro studies with Caco-2 cells.Haem and folate transport by proton-coupled folate transporter/haem carrier protein 1 (SLC46A1).Monoketocholate can decrease transcellular permeation of methotrexate across Caco-2 cell monolayers and reduce its intestinal absorption in rat.Site-specific contribution of proton-coupled folate transporter/haem carrier protein 1 in the intestinal absorption of methotrexate in rats.
P2860
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P2860
Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Functional characterization of ...... cells as a folate transporter
@ast
Functional characterization of ...... cells as a folate transporter
@en
Functional characterization of ...... cells as a folate transporter
@en-gb
Functional characterization of ...... cells as a folate transporter
@nl
type
label
Functional characterization of ...... cells as a folate transporter
@ast
Functional characterization of ...... cells as a folate transporter
@en
Functional characterization of ...... cells as a folate transporter
@en-gb
Functional characterization of ...... cells as a folate transporter
@nl
prefLabel
Functional characterization of ...... cells as a folate transporter
@ast
Functional characterization of ...... cells as a folate transporter
@en
Functional characterization of ...... cells as a folate transporter
@en-gb
Functional characterization of ...... cells as a folate transporter
@nl
P2093
P3181
P356
P1476
Functional characterization of ...... cells as a folate transporter
@en
P2093
Hiroaki Yuasa
Katsuhisa Inoue
Kin-ya Ohta
Mai Hatakeyama
Masaki Otagiri
Yasuhiro Nakai
Yayoi Hayashi
P304
P3181
P356
10.1124/JPET.107.122606
P407
P577
2007-08-01T00:00:00Z