Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
about
PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylaseJmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicingInactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activationMint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathwaysAsparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factorASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanismTranscriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domainsAdenosine and hypoxia-inducible factor signaling in intestinal injury and recoveryHypoxia Induced NF-κBThe Role of Oxygen Sensors, Hydroxylases, and HIF in Cardiac Function and DiseaseEpigenetic regulation by histone demethylases in hypoxiaEvidence That Two Enzyme-derived Histidine Ligands Are Sufficient for Iron Binding and Catalysis by Factor Inhibiting HIF (FIH)Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain foldCrystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylaseRibosomal oxygenases are structurally conserved from prokaryotes to humansSubstrate selectivity analyses of factor inhibiting hypoxia-inducible factorHypoxia: an alarm signal during intestinal inflammationSubstrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling PathwaysFIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1Expanding chemical biology of 2-oxoglutarate oxygenasesInhibition of 2-oxoglutarate dependent oxygenasesPotent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine BrainConsequences of IkappaB alpha hydroxylation by the factor inhibiting HIF (FIH)Crosstalk in NF-κB signaling pathwaysMicroRNA-31 contributes to colorectal cancer development by targeting factor inhibiting HIF-1α (FIH-1)Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response--a predictive kinetic model.The ubiquitin ligase Siah2 and the hypoxia response.The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolismFIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells.Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitorsHuman oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process.Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseasesHypoxia and metabolic factors that influence inflammatory bowel disease pathogenesis.Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer.New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens.Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation.
P2860
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P248
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P2860
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
description
2006 nî lūn-bûn
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2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
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2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
@zh-hant
2006年論文
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2006年論文
@zh-mo
2006年論文
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2006年论文
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name
Posttranslational hydroxylatio ...... e, factor inhibiting HIF (FIH)
@ast
Posttranslational hydroxylatio ...... e, factor inhibiting HIF (FIH)
@en
Posttranslational hydroxylatio ...... e, factor inhibiting HIF (FIH)
@en-gb
Posttranslational hydroxylatio ...... e, factor inhibiting HIF (FIH)
@nl
type
label
Posttranslational hydroxylatio ...... e, factor inhibiting HIF (FIH)
@ast
Posttranslational hydroxylatio ...... e, factor inhibiting HIF (FIH)
@en
Posttranslational hydroxylatio ...... e, factor inhibiting HIF (FIH)
@en-gb
Posttranslational hydroxylatio ...... e, factor inhibiting HIF (FIH)
@nl
prefLabel
Posttranslational hydroxylatio ...... e, factor inhibiting HIF (FIH)
@ast
Posttranslational hydroxylatio ...... e, factor inhibiting HIF (FIH)
@en
Posttranslational hydroxylatio ...... e, factor inhibiting HIF (FIH)
@en-gb
Posttranslational hydroxylatio ...... e, factor inhibiting HIF (FIH)
@nl
P2093
P2860
P50
P921
P356
P1476
Posttranslational hydroxylatio ...... e, factor inhibiting HIF (FIH)
@en
P2093
David E Lancaster
Ineke P Stolze
Kirsty S Hewitson
Norma Masson
Steven C Ley
Xiaohong Yu
P2860
P304
14767-14772
P356
10.1073/PNAS.0606877103
P407
P50
P577
2006-09-26T00:00:00Z