Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death
about
Hexokinase activity is required for recruitment of parkin to depolarized mitochondriaRole of multifaceted regulators in cancer glucose metabolism and their clinical significanceNeuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosisHypoxia-inducible factor 1-mediated characteristic features of cancer cells for tumor radioresistanceRestoration of mitochondria function as a target for cancer therapyThe role of tumor suppressor p53 in the antioxidant defense and metabolismTIGAR contributes to ischemic tolerance induced by cerebral preconditioning through scavenging of reactive oxygen species and inhibition of apoptosisTIGAR is required for efficient intestinal regeneration and tumorigenesisMethyl jasmonate: putative mechanisms of action on cancer cells cycle, metabolism, and apoptosisROS function in redox signaling and oxidative stressTargeting MUC1-C is synergistic with bortezomib in downregulating TIGAR and inducing ROS-mediated myeloma cell death.Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis.Antioxidant supplement inhibits skeletal muscle constitutive autophagy rather than fasting-induced autophagy in mice.Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?Mitochondrial translocation of p53 modulates neuronal fate by preventing differentiation-induced mitochondrial stress.Ferroptosis as a p53-mediated activity during tumour suppressionMetabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy.The return of metabolism: biochemistry and physiology of the pentose phosphate pathwaysiRNA Screening Identifies the Host Hexokinase 2 (HK2) Gene as an Important Hypoxia-Inducible Transcription Factor 1 (HIF-1) Target Gene in Toxoplasma gondii-Infected CellsHypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKTIsoniazid prevents Nrf2 translocation by inhibiting ERK1 phosphorylation and induces oxidative stress and apoptosis.The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology.Prediction and Characterisation of the System Effects of Aristolochic Acid: A Novel Joint Network Analysis towards Therapeutic and Toxicological Mechanisms.Akt phosphorylates HK-II at Thr-473 and increases mitochondrial HK-II association to protect cardiomyocytesMetabolic regulation by p53 family members.Sugar for the brain: the role of glucose in physiological and pathological brain functionCLOCK Promotes Endothelial Damage by Inducing Autophagy through Reactive Oxygen SpeciesIs p53 Involved in Tissue-Specific Insulin Resistance Formation?LKB1 inhibits HPV-associated cancer progression by targeting cellular metabolism.Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?Cellular metabolic and autophagic pathways: traffic control by redox signaling.Proteomics and metabolomics in cancer drug development.The pentose phosphate pathway and cancer.The mitochondrial permeability transition pore and its adaptive responses in tumor cells.ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms.Melatonin ameliorates hypoglycemic stress-induced brain endothelial tight junction injury by inhibiting protein nitration of TP53-induced glycolysis and apoptosis regulator (TIGAR).MicroRNA-124 suppresses proliferation and glycolysis in non-small cell lung cancer cells by targeting AKT-GLUT1/HKII.Modulating the therapeutic response of tumours to dietary serine and glycine starvation.p53- and p73-independent activation of TIGAR expression in vivo.
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P2860
Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death
description
2012 nî lūn-bûn
@nan
2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Mitochondrial localization of ...... and lowers ROS and cell death
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Mitochondrial localization of ...... and lowers ROS and cell death
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Mitochondrial localization of ...... and lowers ROS and cell death
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Mitochondrial localization of ...... and lowers ROS and cell death
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Mitochondrial localization of ...... and lowers ROS and cell death
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Mitochondrial localization of ...... and lowers ROS and cell death
@en
Mitochondrial localization of ...... and lowers ROS and cell death
@en-gb
Mitochondrial localization of ...... and lowers ROS and cell death
@nl
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Mitochondrial localization of ...... and lowers ROS and cell death
@ast
Mitochondrial localization of ...... and lowers ROS and cell death
@en
Mitochondrial localization of ...... and lowers ROS and cell death
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Mitochondrial localization of ...... and lowers ROS and cell death
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Mitochondrial localization of ...... and lowers ROS and cell death
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Eric C Cheung
Karen H Vousden
Robert L Ludwig
P2860
P304
P3181
P356
10.1073/PNAS.1206530109
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P577
2012-12-11T00:00:00Z