A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation

A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation

Item
http://www.wikidata.org/entity/Q24305753
Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiationEpigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cellsPromoting brown and beige adipocyte biogenesis through the PRDM16 pathwayAn emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous systemPPARĪ³ as a therapeutic target to rescue mitochondrial function in neurological diseaseHuman BAT possesses molecular signatures that resemble beige/brite cellsPrdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesisRegulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complexPrdm16 is required for normal palatogenesis in mice.Transcriptional control of brown fat determination by PRDM16PRDM16 expression in the developing mouse embryoThe zinc finger SET domain gene Prdm14 is overexpressed in lymphoblastic lymphomas with retroviral insertions at Evi32.Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells.PRDM Proteins: Molecular Mechanisms in Signal Transduction and Transcriptional Regulation.A survey of well conserved families of C2H2 zinc-finger genes in Daphnia.Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo.Adaptive thermogenesis in adipocytes: is beige the new brown?Transcriptional and epigenetic control of brown and beige adipose cell fate and function.Prdm16 is a physiologic regulator of hematopoietic stem cells.PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program.PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1.Prdm6 is essential for cardiovascular development in vivoSUMOylation of sPRDM16 promotes the progression of acute myeloid leukemia.Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cellsIntegrating physiological regulation with stem cell and tissue homeostasisOverexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in miceHigh incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vectormiR-101 reverses hypomethylation of the PRDM16 promoter to disrupt mitochondrial function in astrocytoma cellsCharacterization of Chicken MMP13 Expression and Genetic Effect on Egg Production Traits of Its Promoter Polymorphisms.Cancer genetics of epigenetic genes.Adipocyte-specific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor gamma and CCAAT/enhancer-binding proteins.Transcriptional control of brown adipocyte development and physiological function--of mice and men.Association of single nucleotide polymorphism Rs2236518 in PRDM16 gene with BMI in Chinese males.PRDM proteins: important players in differentiation and disease.Histone methylation in myelodysplastic syndromes."Browning" of adipose tissue--regulation and therapeutic perspectives.PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing.Functions of Prdm16 in thermogenic fat cells.Identification of a functional estrogen-responsive enhancer element in the promoter 2 of PRDM2 gene in breast cancer cell lines.
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P2860

A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation

Item
http://www.wikidata.org/entity/Q24305753
description
2003 nĆ® lÅ«n-bĆ»n
@nan
2003 Õ©ÕøÖ‚Õ”ÕÆÕ”Õ¶Õ« ՆÕøÕµÕ„Õ“Õ¢Õ„Ö€Õ«Õ¶ Õ°Ö€Õ”ÕæÕ”Ö€Õ”ÕÆÕøÖ‚Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ յօդÕøÖ‚Õ”Õ®
@hyw
2003 Õ©Õ¾Õ”ÕÆÕ”Õ¶Õ« Õ¶ÕøÕµÕ„Õ“Õ¢Õ„Ö€Õ«Õ¶ Õ°Ö€Õ”ÕæÕ”Ö€Õ”ÕÆÕ¾Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ Õ°ÕøÕ¤Õ¾Õ”Õ®
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2003å¹“ć®č«–ę–‡
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2003å¹“č«–ę–‡
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2003å¹“č«–ę–‡
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2003å¹“č«–ę–‡
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2003å¹“č«–ę–‡
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2003å¹“č«–ę–‡
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2003幓č®ŗꖇ
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name
A novel EVI1 gene family, MEL1 ...... nduced myeloid differentiation
@ast
A novel EVI1 gene family, MEL1 ...... nduced myeloid differentiation
@en
A novel EVI1 gene family, MEL1 ...... nduced myeloid differentiation
@en-gb
A novel EVI1 gene family, MEL1 ...... nduced myeloid differentiation
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type
label
A novel EVI1 gene family, MEL1 ...... nduced myeloid differentiation
@ast
A novel EVI1 gene family, MEL1 ...... nduced myeloid differentiation
@en
A novel EVI1 gene family, MEL1 ...... nduced myeloid differentiation
@en-gb
A novel EVI1 gene family, MEL1 ...... nduced myeloid differentiation
@nl
prefLabel
A novel EVI1 gene family, MEL1 ...... nduced myeloid differentiation
@ast
A novel EVI1 gene family, MEL1 ...... nduced myeloid differentiation
@en
A novel EVI1 gene family, MEL1 ...... nduced myeloid differentiation
@en-gb
A novel EVI1 gene family, MEL1 ...... nduced myeloid differentiation
@nl
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A novel EVI1 gene family, MEL1 ...... nduced myeloid differentiation
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10.1182/BLOOD-2002-12-3944
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