Migrastatin analogues target fascin to block tumour metastasis
about
The tumor marker Fascin is induced by the Epstein-Barr virus-encoded oncoprotein LMP1 via NF-κB in lymphocytes and contributes to their invasive migrationProinvasion metastasis drivers in early-stage melanoma are oncogenes.Activation of miR-31 function in already-established metastases elicits metastatic regressionCapturing Biological Activity in Natural Product Fragments by Chemical SynthesisRegulators of Actin Dynamics in Gastrointestinal Tract TumorsTargeting Breast Cancer MetastasisTunneling nanotubes provide a unique conduit for intercellular transfer of cellular contents in human malignant pleural mesotheliomaFascin1-dependent Filopodia are required for directional migration of a subset of neural crest cellsMechanism of Actin Filament Bundling by FascinMolecular Mechanism of Fascin Function in Filopodial FormationMigrastatin analogues inhibit canine mammary cancer cell migration and invasionTumor metastasis: molecular insights and evolving paradigmsA novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability.Actin cross-link assembly and disassembly mechanics for alpha-Actinin and fascin.Intercellular communication in malignant pleural mesothelioma: properties of tunneling nanotubes.An epigenetically distinct breast cancer cell subpopulation promotes collective invasionFascin Rigidity and L-plastin Flexibility Cooperate in Cancer Cell Invadopodia and Filopodia.MYCT1-TV, a novel MYCT1 transcript, is regulated by c-Myc and may participate in laryngeal carcinogenesis.Fascin expression in skull base chordoma: correlation with tumor recurrence and dura erosion.Synaptopodin family of natively unfolded, actin binding proteins: physical properties and potential biological functions.Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.Phytochemicals potently inhibit migration of metastatic breast cancer cellsConfirmation of the Structures of Synthetic Derivatives of Migrastatin in the Light of Recently Disclosed Crystallographically Based Claims.Fascin is a key regulator of breast cancer invasion that acts via the modification of metastasis-associated moleculesA molecular prognostic model predicts esophageal squamous cell carcinoma prognosis.Synthesis and evaluation of antimigratory and antiproliferative activities of lipid-linked [13]-macro-dilactonesFascin overexpression promotes neoplastic progression in oral squamous cell carcinoma.Loss of miR-133a expression associated with poor survival of breast cancer and restoration of miR-133a expression inhibited breast cancer cell growth and invasion.Total syntheses and biological reassessment of lactimidomycin, isomigrastatin and congener glutarimide antibiotics.Fascin is involved in the chemotherapeutic resistance of breast cancer cells predominantly via the PI3K/Akt pathwayA cell-based fascin bioassay identifies compounds with potential anti-metastasis or cognition-enhancing functions.A signal transducer and activator of transcription 3·Nuclear Factor κB (Stat3·NFκB) complex is necessary for the expression of fascin in metastatic breast cancer cells in response to interleukin (IL)-6 and tumor necrosis factor (TNF)-αAntitumor action of a novel histone deacetylase inhibitor, YF479, in breast cancer.Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.FiloDetect: automatic detection of filopodia from fluorescence microscopy images.LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer.Cycloheximide and actiphenol production in Streptomyces sp. YIM56141 governed by single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization.Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin.Total synthesis and biological evaluation of tyroscherin.
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P2860
Migrastatin analogues target fascin to block tumour metastasis
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Migrastatin analogues target fascin to block tumour metastasis
@ast
Migrastatin analogues target fascin to block tumour metastasis
@en
Migrastatin analogues target fascin to block tumour metastasis
@en-gb
Migrastatin analogues target fascin to block tumour metastasis
@nl
type
label
Migrastatin analogues target fascin to block tumour metastasis
@ast
Migrastatin analogues target fascin to block tumour metastasis
@en
Migrastatin analogues target fascin to block tumour metastasis
@en-gb
Migrastatin analogues target fascin to block tumour metastasis
@nl
prefLabel
Migrastatin analogues target fascin to block tumour metastasis
@ast
Migrastatin analogues target fascin to block tumour metastasis
@en
Migrastatin analogues target fascin to block tumour metastasis
@en-gb
Migrastatin analogues target fascin to block tumour metastasis
@nl
P2093
P2860
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Migrastatin analogues target fascin to block tumour metastasis
@en
P2093
J Jillian Zhang
Jean Jakoncic
Shengyu Yang
Xin-Yun Huang
P2860
P2888
P304
P3181
P356
10.1038/NATURE08978
P407
P577
2010-04-15T00:00:00Z
P5875
P6179
1038184843