Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis
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Potential roles for prions and protein-only inheritance in cancerHuman small heat shock proteins: protein interactomes of homo- and hetero-oligomeric complexes: an updateHeat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an updateαB-crystallin/sHSP protects cytochrome c and mitochondrial function against oxidative stress in lens and retinal cellsThe retinal proteome in experimental diabetic retinopathy: up-regulation of crystallins and reversal by systemic and periocular insulinExacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxiaMechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell deathalpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stressTranscriptional regulation of PP2A-A alpha is mediated by multiple factors including AP-2alpha, CREB, ETS-1, and SP-1alphaB-crystallin regulation of angiogenesis by modulation of VEGF.αB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cellsalphaB-crystallin is a marker of aggressive breast cancer behavior but does not independently predict for patient outcome: a combined analysis of two randomized studies.Advanced glycation endproduct-induced aging of the retinal pigment epithelium and choroid: a comprehensive transcriptional response.Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation.AlphaB-crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer.Effect of dimerized thrombin fragment TP508 on acute myocardial ischemia reperfusion injury in hypercholesterolemic swineMechanistic insight into the ability of American ginseng to suppress colon cancer associated with colitis.Alexander disease causing mutations in the C-terminal domain of GFAP are deleterious both to assembly and network formation with the potential to both activate caspase 3 and decrease cell viability.The small heat shock protein HspB2 is a novel anti-apoptotic protein that inhibits apical caspase activation in the extrinsic apoptotic pathway.Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B.Serine 59 phosphorylation of {alpha}B-crystallin down-regulates its anti-apoptotic function by binding and sequestering Bcl-2 in breast cancer cells.Molecular mechanism of formation of cortical opacity in CRYAAN101D transgenic mice.A potential role of crystallin in the vitreous bodies of rats after ischemia-reperfusion injury.ERK-regulated αB-crystallin induction by matrix detachment inhibits anoikis and promotes lung metastasis in vivo.AlphaB-crystallin is found in detergent-resistant membrane microdomains and is secreted via exosomes from human retinal pigment epithelial cellsAnalysis of the cytoprotective role of α-crystallins in cell survival and implication of the αA-crystallin C-terminal extension domain in preventing Bax-induced apoptosisExpression of alpha-crystallins in human sebaceous carcinoma of the eyelid.Expression of heat shock protein 27 and alpha-crystallins in human retinoblastoma after chemoreduction.Knockdown of Akt1 promotes Akt2 upregulation and resistance to oxidative-stress-induced apoptosis through control of multiple signaling pathwaysStrain-independent increases of crystallin proteins in the retina of type 1 diabetic rats.Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activitiesAnalysis of Bcl-2 protein expression in choroidal melanomasImpact of Subunit Composition on the Uptake of α-Crystallin by Lens and RetinaMechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH effluxAdult neuron survival strategies--slamming on the brakes.Therapeutic effects of systemic administration of chaperone αB-crystallin associated with binding proinflammatory plasma proteins.Expression of alpha B crystallin and BCL2 in patients with infiltrating ductal carcinomaAlpha B-Crystallin Protects Rat Articular Chondrocytes against Casein Kinase II Inhibition-Induced ApoptosisDeficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunctionNovel roles for α-crystallins in retinal function and disease.
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P2860
Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis
description
2004 nî lūn-bûn
@nan
2004 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
name
Human alphaA- and alphaB-cryst ...... taurosporine-induced apoptosis
@ast
Human alphaA- and alphaB-cryst ...... taurosporine-induced apoptosis
@en
Human alphaA- and alphaB-cryst ...... taurosporine-induced apoptosis
@en-gb
Human alphaA- and alphaB-cryst ...... taurosporine-induced apoptosis
@nl
type
label
Human alphaA- and alphaB-cryst ...... taurosporine-induced apoptosis
@ast
Human alphaA- and alphaB-cryst ...... taurosporine-induced apoptosis
@en
Human alphaA- and alphaB-cryst ...... taurosporine-induced apoptosis
@en-gb
Human alphaA- and alphaB-cryst ...... taurosporine-induced apoptosis
@nl
prefLabel
Human alphaA- and alphaB-cryst ...... taurosporine-induced apoptosis
@ast
Human alphaA- and alphaB-cryst ...... taurosporine-induced apoptosis
@en
Human alphaA- and alphaB-cryst ...... taurosporine-induced apoptosis
@en-gb
Human alphaA- and alphaB-cryst ...... taurosporine-induced apoptosis
@nl
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Human alphaA- and alphaB-cryst ...... taurosporine-induced apoptosis
@en
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P2888
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P3181
P356
10.1038/SJ.CDD.4401384
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P50
P577
2004-05-01T00:00:00Z
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1050311064