Single nucleotide polymorphism of the human high affinity choline transporter alters transport rate
about
Cholinergic capacity mediates prefrontal engagement during challenges to attention: evidence from imaging genetics.Impaired Presynaptic High-Affinity Choline Transporter Causes a Congenital Myasthenic Syndrome with Episodic ApneaPar-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membraneNuclear choline acetyltransferase activates transcription of a high-affinity choline transporterConstitutive high-affinity choline transporter endocytosis is determined by a carboxyl-terminal tail dileucine motifRegulation of the high-affinity choline transporter activity and trafficking by its association with cholesterol-rich lipid raftsReduction in CHT1-mediated choline uptake in primary neurons from presenilin-1 M146V mutant knock-in miceLethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout miceTachycardia, reduced vagal capacity, and age-dependent ventricular dysfunction arising from diminished expression of the presynaptic choline transporter.Choline transporter gene variation is associated with attention-deficit hyperactivity disorder.Basal forebrain moderates the magnitude of task-dependent amygdala functional connectivityDisposed to distraction: genetic variation in the cholinergic system influences distractibility but not time-on-task effects.Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise.Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in ratsAre there non-catalytic functions of acetylcholinesterases? Lessons from mutant animal models.Polymorphic variation in choline transporter gene (CHT1) is associated with early, subclinical measures of carotid atherosclerosis in humansThe "ins" and "outs" of the high-affinity choline transporter CHT1.The presynaptic choline transporter imposes limits on sustained cortical acetylcholine release and attentionModeling neurodevelopmental cognitive deficits in tasks with cross-species translational validityMultivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.Monitoring cholinergic activity during attentional performance in mice heterozygous for the choline transporter: a model of cholinergic capacity limits.The role of phosphatidylcholine and choline metabolites to cell proliferation and survival.Hemicholinium-3 sensitive choline transport in human T lymphocytes: Evidence for use as a proxy for brain choline transporter (CHT) capacity.Cholinergic genetics of visual attention: Human and mouse choline transporter capacity variants influence distractibility.Differential impact of genetically modulated choline transporter expression on the release of endogenous versus newly synthesized acetylcholine.Transmembrane topology and oligomeric structure of the high-affinity choline transporter.A mechanism for suppression of the CDP-choline pathway during apoptosis.Expression of the high-affinity choline transporter CHT1 in rat and human arteries.A single nucleotide polymorphism alters the activity of the renal Na+:Cl- cotransporter and reveals a role for transmembrane segment 4 in chloride and thiazide affinity.Rapid assessment of in vivo cholinergic transmission by amperometric detection of changes in extracellular choline levels.Choline transporter mutations in severe congenital myasthenic syndrome disrupt transporter localization.The Neuroscience of Cognitive-Motivational Styles: Sign- and Goal-Trackers as Animal Models.
P2860
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P2860
Single nucleotide polymorphism of the human high affinity choline transporter alters transport rate
description
2002 nî lūn-bûn
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2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年學術文章
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name
Single nucleotide polymorphism ...... nsporter alters transport rate
@ast
Single nucleotide polymorphism ...... nsporter alters transport rate
@en
Single nucleotide polymorphism ...... nsporter alters transport rate
@en-gb
Single nucleotide polymorphism ...... nsporter alters transport rate
@nl
type
label
Single nucleotide polymorphism ...... nsporter alters transport rate
@ast
Single nucleotide polymorphism ...... nsporter alters transport rate
@en
Single nucleotide polymorphism ...... nsporter alters transport rate
@en-gb
Single nucleotide polymorphism ...... nsporter alters transport rate
@nl
prefLabel
Single nucleotide polymorphism ...... nsporter alters transport rate
@ast
Single nucleotide polymorphism ...... nsporter alters transport rate
@en
Single nucleotide polymorphism ...... nsporter alters transport rate
@en-gb
Single nucleotide polymorphism ...... nsporter alters transport rate
@nl
P2093
P2860
P356
P1476
Single nucleotide polymorphism ...... nsporter alters transport rate
@en
P2093
China Kaitsuka
David Gurwitz
Michiko Okamura
Takashi Okuda
Tatsuya Haga
P2860
P304
P356
10.1074/JBC.M207742200
P407
P577
2002-11-22T00:00:00Z