Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene
about
Long-lived plasma cells and memory B cells produce pathogenic anti-GAD65 autoantibodies in Stiff Person SyndromeAdult and embryonic GAD transcripts are spatiotemporally regulated during postnatal development in the rat brainMolecular cloning of the mature NAD(+)-dependent succinic semialdehyde dehydrogenase from rat and human. cDNA isolation, evolutionary homology, and tissue expressionQuantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes typeDynamic expression of a glutamate decarboxylase gene in multiple non-neural tissues during mouse developmentHomozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disordersRoles of glutamine synthetase inhibition in epilepsyHypoxic preconditioning differentially affects GABAergic and glutamatergic neuronal cells in the injured cerebellum of the neonatal ratMapping autoantigen epitopes: molecular insights into autoantibody-associated disorders of the nervous systemGABA and glutamate in the human brainAutoimmune type 1 diabetes: resolved and unresolved issuesThe components required for amino acid neurotransmitter signaling are present in adipose tissuesPhosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alphaGlutamatergic synaptic dysregulation in schizophrenia: therapeutic implications.GAD65 antibodies, chronic psychosis, and type 2 diabetes mellitusCofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasisSex steroid regulation of glutamate decarboxylase mRNA expression in goldfish brain is sexually dimorphic.Nucleotide sequence and chromosomal assignment of a cDNA encoding the large isoform of human glutamate decarboxylase.cDNA encoding the chicken ortholog of the mouse dilute gene product. Sequence comparison reveals a myosin I subfamily with conserved C-terminal domains.Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding.Escherichia coli has two homologous glutamate decarboxylase genes that map to distinct loci.The GABA paradox: multiple roles as metabolite, neurotransmitter, and neurodifferentiative agent.Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression.An examination of aspartate decarboxylase and glutamate decarboxylase activity in mosquitoes.Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clustersIncreased GAD expression in the striatum after transient cerebral ischemiaThe physiological roles of vesicular GABA transporter during embryonic development: a study using knockout mice.The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba.GABAergic signaling in the pulmonary neuroepithelial body microenvironment: functional imaging in GAD67-GFP mice.Glutamic acid decarboxylase 67 expression by a distinct population of mouse vestibular supporting cellsGlutamate decarboxylase 67 is expressed in hippocampal mossy fibers of temporal lobe epilepsy patients.Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neuronsA Transgenic Mouse Line Expressing the Red Fluorescent Protein tdTomato in GABAergic Neurons.Antigen-specific therapeutic approaches in Type 1 diabetesIslet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetesGAD2 Alternative Transcripts in the Human Prefrontal Cortex, and in Schizophrenia and Affective Disorders.Relationships among 64k autoantibodies, pancreatic beta-cell function, HLA-DR antigens and HLA-DQ genes in patients with insulin-dependent diabetes mellitus in Korea.Functional Differentiation of Cholecystokinin-Containing Interneurons Destined for the Cerebral Cortex.Astrocytic regulation of glutamate homeostasis in epilepsyBrain stem excitatory and inhibitory signaling pathways regulating bronchoconstrictive responses.
P2860
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P2860
Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene
description
1992 nî lūn-bûn
@nan
1992 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի մարտին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Two human glutamate decarboxyl ...... each encoded by a single gene
@ast
Two human glutamate decarboxyl ...... each encoded by a single gene
@en
Two human glutamate decarboxyl ...... each encoded by a single gene
@en-gb
Two human glutamate decarboxyl ...... each encoded by a single gene
@nl
type
label
Two human glutamate decarboxyl ...... each encoded by a single gene
@ast
Two human glutamate decarboxyl ...... each encoded by a single gene
@en
Two human glutamate decarboxyl ...... each encoded by a single gene
@en-gb
Two human glutamate decarboxyl ...... each encoded by a single gene
@nl
prefLabel
Two human glutamate decarboxyl ...... each encoded by a single gene
@ast
Two human glutamate decarboxyl ...... each encoded by a single gene
@en
Two human glutamate decarboxyl ...... each encoded by a single gene
@en-gb
Two human glutamate decarboxyl ...... each encoded by a single gene
@nl
P2093
P2860
P921
P3181
P356
P1476
Two human glutamate decarboxyl ...... each encoded by a single gene
@en
P2093
C B Wagner-McPherson
D L Kaufman
M G Erlander
N J Tillakaratne
P2860
P304
P3181
P356
10.1073/PNAS.89.6.2115
P407
P577
1992-03-15T00:00:00Z