Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity - Test2 - elhamkhani - TriplyDB

Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity

Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity

http://www.wikidata.org/entity/Q24308001

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Nanopatterned Human iPSC-Based Model of a Dystrophin-Null Cardiomyopathic Phenotype Arrhythmia caused by a Drosophila tropomyosin mutation is revealed using a novel optical coherence tomography instrument Research priorities in sarcomeric cardiomyopathies Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivity Tropomyosin de-phosphorylation in the heart: what are the consequences?Thin filament mutations: developing an integrative approach to a complex disorder Combinatorial effects of double cardiomyopathy mutant alleles in rodent myocytes: a predictive cellular model of myofilament dysregulation in disease Removal of the cardiac troponin I N-terminal extension improves cardiac function in aged mice.Thin filament incorporation of an engineered cardiac troponin C variant (L48Q) enhances contractility in intact cardiomyocytes from healthy and infarcted hearts.Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform Omecamtiv Mecarbil, a Cardiac Myosin Activator, Increases Ca2+ Sensitivity in Myofilaments With a Dilated Cardiomyopathy Mutant Tropomyosin E54K.Rescue of familial cardiomyopathies by modifications at the level of sarcomere and Ca2+ fluxes.Investigations into tropomyosin function using mouse models Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy.DCM-related tropomyosin mutants E40K/E54K over-inhibit the actomyosin interaction and lead to a decrease in the number of cycling cross-bridges.Functional effects of a tropomyosin mutation linked to FHC contribute to maladaptation during acidosis Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin.Tropomyosin isoforms and reagents SERCA2 Haploinsufficiency in a Mouse Model of Darier Disease Causes a Selective Predisposition to Heart Failure Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model.A dilated cardiomyopathy mutation blunts adrenergic response and induces contractile dysfunction under chronic angiotensin II stress Tropomyosin dephosphorylation results in compensated cardiac hypertrophy Conserved Asp-137 is important for both structure and regulatory functions of cardiac α-tropomyosin (α-TM) in a novel transgenic mouse model expressing α-TM-D137L Use of 2-D DIGE analysis reveals altered phosphorylation in a tropomyosin mutant (Glu54Lys) linked to dilated cardiomyopathy.A myosin activator improves actin assembly and sarcomere function of human-induced pluripotent stem cell-derived cardiomyocytes with a troponin T point mutation.Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity.An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity Chronic intermittent hypoxia increases left ventricular contractility in C57BL/6J mice.How do mutations in contractile proteins cause the primary familial cardiomyopathies?A study of tropomyosin's role in cardiac function and disease using thin-filament reconstituted myocardium.Genetics in dilated cardiomyopathy.Alpha-tropomyosin mutations in inherited cardiomyopathies.Myofilament dysfunction as an emerging mechanism of volume overload heart failure.Experimental models of inherited cardiomyopathy and its therapeutics.Tetrodotoxin-sensitive Ca2+ Currents, but No T-type Currents in Normal, Hypertrophied, and Failing Mouse Cardiomyocytes.Early sensitization of myofilaments to Ca2+ prevents genetically linked dilated cardiomyopathy in mice.Challenging current paradigms related to cardiomyopathies. Are changes in the Ca2+ sensitivity of myofilaments containing cardiac troponin C mutations (G159D and L29Q) good predictors of the phenotypic outcomes?Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation.Phenotypic heterogeneity of sarcomeric gene mutations: a matter of gain and loss?Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice.

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Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity

http://www.wikidata.org/entity/Q24308001

description

2007 nî lūn-bûn

@nan

2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի հուլիսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity

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Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity

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Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity

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Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity

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type

label

Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity

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Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity

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Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity

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Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity

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Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity

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Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity

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Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity

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Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity

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CIRCRESAHA.107.148379

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Circulation Research

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Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity

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Beata M Wolska

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Dalia Urboniene

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David F Wieczorek

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Ganapathy Jagatheesan

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Grace M Arteaga

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Greg P Boivin

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Natalia Petrashevskaya

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R John Solaro

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Rafeeq P H Ahmed

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Stephen B Liggett

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205-14

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scholarly article

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10.1161/CIRCRESAHA.107.148379

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2

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2007-07-20T00:00:00Z

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Tropomyosin 1, alpha

positive regulation of heart rate by epinephrine