Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity
about
Nanopatterned Human iPSC-Based Model of a Dystrophin-Null Cardiomyopathic PhenotypeArrhythmia caused by a Drosophila tropomyosin mutation is revealed using a novel optical coherence tomography instrumentResearch priorities in sarcomeric cardiomyopathiesFamilial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivityTropomyosin de-phosphorylation in the heart: what are the consequences?Thin filament mutations: developing an integrative approach to a complex disorderCombinatorial effects of double cardiomyopathy mutant alleles in rodent myocytes: a predictive cellular model of myofilament dysregulation in diseaseRemoval of the cardiac troponin I N-terminal extension improves cardiac function in aged mice.Thin filament incorporation of an engineered cardiac troponin C variant (L48Q) enhances contractility in intact cardiomyocytes from healthy and infarcted hearts.Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoformOmecamtiv Mecarbil, a Cardiac Myosin Activator, Increases Ca2+ Sensitivity in Myofilaments With a Dilated Cardiomyopathy Mutant Tropomyosin E54K.Rescue of familial cardiomyopathies by modifications at the level of sarcomere and Ca2+ fluxes.Investigations into tropomyosin function using mouse modelsInvestigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy.DCM-related tropomyosin mutants E40K/E54K over-inhibit the actomyosin interaction and lead to a decrease in the number of cycling cross-bridges.Functional effects of a tropomyosin mutation linked to FHC contribute to maladaptation during acidosisStructural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin.Tropomyosin isoforms and reagentsSERCA2 Haploinsufficiency in a Mouse Model of Darier Disease Causes a Selective Predisposition to Heart FailureCardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model.A dilated cardiomyopathy mutation blunts adrenergic response and induces contractile dysfunction under chronic angiotensin II stressTropomyosin dephosphorylation results in compensated cardiac hypertrophyConserved Asp-137 is important for both structure and regulatory functions of cardiac α-tropomyosin (α-TM) in a novel transgenic mouse model expressing α-TM-D137LUse of 2-D DIGE analysis reveals altered phosphorylation in a tropomyosin mutant (Glu54Lys) linked to dilated cardiomyopathy.A myosin activator improves actin assembly and sarcomere function of human-induced pluripotent stem cell-derived cardiomyocytes with a troponin T point mutation.Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity.An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivityChronic intermittent hypoxia increases left ventricular contractility in C57BL/6J mice.How do mutations in contractile proteins cause the primary familial cardiomyopathies?A study of tropomyosin's role in cardiac function and disease using thin-filament reconstituted myocardium.Genetics in dilated cardiomyopathy.Alpha-tropomyosin mutations in inherited cardiomyopathies.Myofilament dysfunction as an emerging mechanism of volume overload heart failure.Experimental models of inherited cardiomyopathy and its therapeutics.Tetrodotoxin-sensitive Ca2+ Currents, but No T-type Currents in Normal, Hypertrophied, and Failing Mouse Cardiomyocytes.Early sensitization of myofilaments to Ca2+ prevents genetically linked dilated cardiomyopathy in mice.Challenging current paradigms related to cardiomyopathies. Are changes in the Ca2+ sensitivity of myofilaments containing cardiac troponin C mutations (G159D and L29Q) good predictors of the phenotypic outcomes?Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation.Phenotypic heterogeneity of sarcomeric gene mutations: a matter of gain and loss?Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice.
P2860
Q26779454-A4BF3D97-C574-4BC6-BE41-88CB1EF08134Q27315223-FB5B3C40-22C3-4E32-BC16-577798DB6BF2Q27694507-2D3BE44B-1528-4CDA-B8CE-C5A5852EE1EEQ28287994-348F9E60-C535-4217-A91E-34AE2E8CC078Q28293301-20E80323-AE33-4A74-9644-54D58B9CA6B0Q28307606-EED8A049-BFE4-493C-87CD-472F48415CC3Q28472836-DB4F4923-C686-4810-907D-AFD4EFA6C788Q30475106-C1782AEA-90F1-482B-90B7-4BB54C721BC5Q30582828-CB9DB434-2A6A-4714-9A25-51B4E5369440Q33656587-2C2E2949-17C1-464F-9873-A0778E4AB0D8Q33768442-35D1DDC9-1E24-4F85-95F8-B8576DE63CE3Q33787794-96914469-A6DF-47D6-9201-5CEF19C84D9EQ33854803-3DFA4AE1-29BC-4088-A3A6-9B011A0928D6Q34080849-076996E1-8982-453C-9EB3-E5F6462060B4Q34450885-CADF9DC0-B5EC-4872-BBA9-7655A0377D67Q34561038-00F339D6-FDEF-4BE7-90B2-2662C7B5BCC5Q34608346-A175EAAF-C8AB-4B50-8B08-5E4B00658854Q35534685-89C4B63E-74B5-476A-8678-0B72C3F319A5Q35612469-FFCB653D-CA14-49C7-BCB8-BD2467595B40Q36048967-B24D9F2C-C879-44D9-9C7C-D7CEE01B17ACQ36422401-65511DB7-4B11-48F0-BA68-8754CF33C829Q36492849-9854E110-B913-4572-B22C-85BA2416A116Q36910012-46D42E9C-2723-48BE-BEB1-AB3A30744BBFQ36982376-34844DEA-D2B1-4AA6-B7F5-10652DAE42CCQ37139621-297E6AE8-1786-41D2-8E9B-73C9A5939B36Q37247513-5AF6C398-C9E0-44FD-A742-CEC930503423Q37264422-463141D4-A096-42F0-A6F5-B115C79042DAQ37372426-5610ACBC-82F4-40EF-9325-C02FDD8FD2D0Q37855688-62577C94-21B2-428A-A8DB-6925CDD27B42Q38108764-8A7B0EE9-4ACB-4EDF-A225-FE338964D144Q38125766-567BAEAC-9E29-45E9-905E-4BE600F86EC9Q38134256-5C733E5D-94E6-4760-83C4-5E00E3A3A837Q38184400-97B29409-0E07-43C6-A318-B1605EB9F783Q38303620-38F61AF8-0F96-42EF-880F-8EEBCC33A692Q38822292-38594A49-A4BE-4AF7-99B0-1D675F39DF4AQ38853345-5622908E-F9C5-419D-BC94-3D8EFF3CDF15Q41679671-92162A69-C168-4AC4-AD75-6C491CF99B41Q41901024-59A6383A-ED05-4CD1-A2BC-F046B84480E4Q42576065-C9F6C237-B2C3-40E9-9A0E-82F7EB235F11Q49790570-A3CC89B2-B0D8-4734-B0FF-23C980B485A6
P2860
Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity
description
2007 nî lūn-bûn
@nan
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity
@ast
Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity
@en
Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity
@en-gb
Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity
@nl
type
label
Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity
@ast
Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity
@en
Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity
@en-gb
Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity
@nl
prefLabel
Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity
@ast
Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity
@en
Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity
@en-gb
Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity
@nl
P2093
P921
P1433
P1476
Dilated cardiomyopathy mutant ...... yofilament calcium sensitivity
@en
P2093
Beata M Wolska
Dalia Urboniene
David F Wieczorek
Ganapathy Jagatheesan
Grace M Arteaga
Greg P Boivin
Natalia Petrashevskaya
R John Solaro
Rafeeq P H Ahmed
Stephen B Liggett
P304
P356
10.1161/CIRCRESAHA.107.148379
P407
P577
2007-07-20T00:00:00Z