Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases
about
A missense mutation in the SERPINH1 gene in Dachshunds with osteogenesis imperfectaActive site distortion is sufficient for proteinase inhibition by serpins: structure of the covalent complex of alpha1-proteinase inhibitor with porcine pancreatic elastaseAntithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activationAn overview of the serpin superfamilyStructure of native protein C inhibitor provides insight into its multiple functionsIn silico assessment of potential druggable pockets on the surface of α1-antitrypsin conformersExperimental Data in Support of a Direct Displacement Mechanism for Type I/II L-Asparaginases.Collapse of a long axis: single-molecule Förster resonance energy transfer and serpin equilibrium unfolding.N-glycans of human protein C inhibitor: tissue-specific expression and function.Comparison of tertiary structures of proteins in protein-protein complexes with unbound forms suggests prevalence of allostery in signalling proteins.Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs).Protein misfolding and the serpinopathies.Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition.Structure-function relationship of SW-AT-1, a serpin-type protease inhibitor in silkworm.Energy landscapes of functional proteins are inherently risky.Crystal Structure of the Michaelis Complex between Tissue-type Plasminogen Activator and Plasminogen Activators Inhibitor-1.Pathogenic cellular role of the p.L104P human cationic trypsinogen variant in chronic pancreatitisIdentification of serpin determinants of specificity and selectivity for furin inhibition through studies of α1PDX (α1-protease inhibitor Portland)-serpin B8 and furin active-site loop chimerasKinetic intermediates en route to the final serpin-protease complex: studies of complexes of α1-protease inhibitor with trypsinVaspin (serpinA12) in obesity, insulin resistance, and inflammation.The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity.Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease.Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance.Assessing the performance of the MM/PBSA and MM/GBSA methods. 6. Capability to predict protein-protein binding free energies and re-rank binding poses generated by protein-protein docking.Characterization of Protein Z-Dependent Protease Inhibitor/Antithrombin Chimeras Provides Insight into the Serpin Specificity of Coagulation Proteases.Short-lived protease serpin complexes: partial disruption of the rat trypsin active site.Engineering functional antithrombin exosites in alpha1-proteinase inhibitor that specifically promote the inhibition of factor Xa and factor IXa.How the serpin α1-proteinase inhibitor folds.Specificity and reactive loop length requirements for crmA inhibition of serine proteases.alpha1-Proteinase inhibitor forms initial non-covalent and final covalent complexes with elastase analogously to other serpin-proteinase pairs, suggesting a common mechanism of inhibition.Streptococcal pyogenic exotoxin B (SpeB) boosts the contact system via binding of α-1 antitrypsin.Molecular bases of neuroserpin function and pathology.The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions.
P2860
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P2860
Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Canonical inhibitor-like inter ...... antithrombin with proteinases
@ast
Canonical inhibitor-like inter ...... antithrombin with proteinases
@en
Canonical inhibitor-like inter ...... antithrombin with proteinases
@en-gb
Canonical inhibitor-like inter ...... antithrombin with proteinases
@nl
type
label
Canonical inhibitor-like inter ...... antithrombin with proteinases
@ast
Canonical inhibitor-like inter ...... antithrombin with proteinases
@en
Canonical inhibitor-like inter ...... antithrombin with proteinases
@en-gb
Canonical inhibitor-like inter ...... antithrombin with proteinases
@nl
prefLabel
Canonical inhibitor-like inter ...... antithrombin with proteinases
@ast
Canonical inhibitor-like inter ...... antithrombin with proteinases
@en
Canonical inhibitor-like inter ...... antithrombin with proteinases
@en-gb
Canonical inhibitor-like inter ...... antithrombin with proteinases
@nl
P2093
P2860
P356
P1476
Canonical inhibitor-like inter ...... antithrombin with proteinases
@en
P2093
Alexey Dementiev
Miljan Simonovic
Peter G W Gettins
P2860
P304
P356
10.1074/JBC.M305195200
P407
P577
2003-09-26T00:00:00Z