BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production
about
CD74 interacts with APP and suppresses the production of AbetaBRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2BRI2 (ITM2b) inhibits Abeta deposition in vivoGeneration and initial characterization of FDD knock in miceAPP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutantModeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficitsGenetic alterations of the BRI2 gene: familial British and Danish dementias.An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss.Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro.Glycosylation of BRI2 on asparagine 170 is involved in its trafficking to the cell surface but not in its processing by furin or ADAM10.Memory deficits of British dementia knock-in mice are prevented by Aβ-precursor protein haploinsufficiency.Proteomic characterization of a mouse model of familial Danish dementia.β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia.Lessons from a Rare Familial Dementia: Amyloid and Beyond.Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia.Cerebral amyloidosis: amyloid subunits, mutants and phenotypes.Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance.Ectodomain shedding of the amyloid precursor protein: cellular control mechanisms and novel modifiers.APP Receptor? To Be or Not To Be.Increased AβPP processing in familial Danish dementia patients.Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memoryBRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate.BRI2 homodimerizes with the involvement of intermolecular disulfide bonds.Expression of BRI2 mRNA and protein in normal human brain and familial British dementia: its relevance to the pathogenesis of diseaseAmyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia.BRI2 interacts with BACE1 and regulates its cellular levels by promoting its degradation and reducing its mRNA levels.Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APPBRICHOS domain associated with lung fibrosis, dementia and cancer--a chaperone that prevents amyloid fibril formation?BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).The familial dementia gene revisited: a missense mutation revealed by whole-exome sequencing identifies ITM2B as a candidate gene underlying a novel autosomal dominant retinal dystrophy in a large family.The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases.BRI2 ectodomain affects Aβ42 fibrillation and tau truncation in human neuroblastoma cells.Transthyretin and BRICHOS: The Paradox of Amyloidogenic Proteins with Anti-Amyloidogenic Activity for Aβ in the Central Nervous System.Type 3 Diabetes: Cross Talk between Differentially Regulated Proteins of Type 2 Diabetes Mellitus and Alzheimer's Disease.Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesiclesCEREBRAL AMYLOID ANGIOPATHY AND ALZHEIMER'S DISEASE.Amyloid and intracellular accumulation of BRI2.Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation.Isobaric Tag-Based Protein Profiling of a Nicotine-Treated Alpha7 Nicotinic Receptor-Null Human Haploid Cell Line.
P2860
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P2860
BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
BRI2 interacts with amyloid pr ...... myloid beta (Abeta) production
@ast
BRI2 interacts with amyloid pr ...... myloid beta (Abeta) production
@en
BRI2 interacts with amyloid pr ...... myloid beta (Abeta) production
@en-gb
BRI2 interacts with amyloid pr ...... myloid beta (Abeta) production
@nl
type
label
BRI2 interacts with amyloid pr ...... myloid beta (Abeta) production
@ast
BRI2 interacts with amyloid pr ...... myloid beta (Abeta) production
@en
BRI2 interacts with amyloid pr ...... myloid beta (Abeta) production
@en-gb
BRI2 interacts with amyloid pr ...... myloid beta (Abeta) production
@nl
prefLabel
BRI2 interacts with amyloid pr ...... myloid beta (Abeta) production
@ast
BRI2 interacts with amyloid pr ...... myloid beta (Abeta) production
@en
BRI2 interacts with amyloid pr ...... myloid beta (Abeta) production
@en-gb
BRI2 interacts with amyloid pr ...... myloid beta (Abeta) production
@nl
P2093
P2860
P3181
P356
P1476
BRI2 interacts with amyloid pr ...... myloid beta (Abeta) production
@en
P2093
Agueda Rostagno
Alexandros Poulopoulos
Angeliki Fotinopoulou
Blas Frangione
Jorge Ghiso
Maria Tsachaki
Maria Vlavaki
Spiros Efthimiopoulos
P2860
P304
P3181
P356
10.1074/JBC.C500231200
P407
P577
2005-09-02T00:00:00Z