Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid
about
A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to RhoA single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acidSphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangementMAGI-3 regulates LPA-induced activation of Erk and RhoARegulation of T cell motility in vitro and in vivo by LPA and LPA2Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptorsDual mechanisms for lysophosphatidic acid stimulation of human ovarian carcinoma cellsSphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218A rat G protein-coupled receptor selectively expressed in myelin-forming cellsEdg-2 in myelin-forming cells: isoforms, genomic mapping, and exclusion in Charcot-Marie-Tooth diseaseLysophosphatidic acid enhances healing of acute cutaneous wounds in the mouse.Cleft lip and palate genetics and application in early embryological development.Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance.LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1β releaseCharacterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2).Distribution of endogenous farnesyl pyrophosphate and four species of lysophosphatidic acid in rodent brain.The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastasesRoles of atypical protein kinase C in lysophosphatidic acid-induced type II adenylyl cyclase activation in RAW 264.7 macrophagesProgress in methodology. Improved reporter gene assays used to identify ligands acting on orphan seven-transmembrane receptors.Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils.Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Krüppel-like factor 5.Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acidReceptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells.Lysophosphatidic acid signaling in airway epithelium: role in airway inflammation and remodeling.Alpha2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes. A paracrine signal for preadipocyte growthLysophosphatidic acid enhances pulmonary epithelial barrier integrity and protects endotoxin-induced epithelial barrier disruption and lung injury.Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma.Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer.Lysophosphatidic acid activates NF-kappaB in fibroblasts. A requirement for multiple inputs.VRQ397 (CRAVKY): a novel noncompetitive V2 receptor antagonist.Identification of residues responsible for ligand recognition and regioisomeric selectivity of lysophosphatidic acid receptors expressed in mammalian cells.Phosphorylation and desensitization of the lysophosphatidic acid receptor LPA1.A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors.Synergism among lysophosphatidic acid, beta1A integrins, and epidermal growth factor or platelet-derived growth factor in mediation of cell migration.Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kinase and phosphoinositide 3-kinaseLysophosphatidic acid prevents apoptosis of Caco-2 colon cancer cells via activation of mitogen-activated protein kinase and phosphorylation of Bad.Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells.Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1.Gelsolin and functionally similar actin-binding proteins are regulated by lysophosphatidic acid.Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist.
P2860
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P2860
Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid
description
1997 nî lūn-bûn
@nan
1997 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Molecular cloning of the human ...... ptor for lysophosphatidic acid
@ast
Molecular cloning of the human ...... ptor for lysophosphatidic acid
@en
Molecular cloning of the human ...... ptor for lysophosphatidic acid
@en-gb
Molecular cloning of the human ...... ptor for lysophosphatidic acid
@nl
type
label
Molecular cloning of the human ...... ptor for lysophosphatidic acid
@ast
Molecular cloning of the human ...... ptor for lysophosphatidic acid
@en
Molecular cloning of the human ...... ptor for lysophosphatidic acid
@en-gb
Molecular cloning of the human ...... ptor for lysophosphatidic acid
@nl
prefLabel
Molecular cloning of the human ...... ptor for lysophosphatidic acid
@ast
Molecular cloning of the human ...... ptor for lysophosphatidic acid
@en
Molecular cloning of the human ...... ptor for lysophosphatidic acid
@en-gb
Molecular cloning of the human ...... ptor for lysophosphatidic acid
@nl
P2093
P356
P1476
Molecular cloning of the human ...... ptor for lysophosphatidic acid
@en
P2093
P304
P356
10.1006/BBRC.1997.6150
P407
P577
1997-02-24T00:00:00Z