Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression
about
Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signallingVprBP has intrinsic kinase activity targeting histone H2A and represses gene transcriptionEpigenetic modifications in double-strand break DNA damage signaling and repairImplication of posttranslational histone modifications in nucleotide excision repairA peek into the complex realm of histone phosphorylationThe Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and HistonesEssential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosisSystematic screen reveals new functional dynamics of histones H3 and H4 during gametogenesisAcetylation Reader Proteins: Linking Acetylation Signaling to Genome Maintenance and CancerDNA damage control: regulation and functions of checkpoint kinase 1Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?Checkpoint kinase 1 in DNA damage response and cell cycle regulationRoles of Chk1 in cell biology and cancer therapyHuman mitochondrial Fis1 links to cell cycle regulators at G2/M transitionChk1 targeting reactivates PP2A tumor suppressor activity in cancer cellsVIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signalingMammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-κB signaling pathway.Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1.Chk1 haploinsufficiency results in anemia and defective erythropoiesis.Novel positive feedback loop between Cdk1 and Chk1 in the nucleus during G2/M transition.Caffeine prevents transcription inhibition and P-TEFb/7SK dissociation following UV-induced DNA damage.Ataxin-3 promotes genome integrity by stabilizing Chk1.Activation of CHK1 in Supporting Cells Indirectly Promotes Hair Cell SurvivalChromatin at the intersection of viral infection and DNA damageThe G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapyThe anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sitesHepatitis C virus NS5B protein delays s phase progression in human hepatocyte-derived cells by relocalizing cyclin-dependent kinase 2-interacting protein (CINP).Histone XH2AX is required for Xenopus anterior neural development: critical role of threonine 16 phosphorylation.Substitutions in the amino-terminal tail of neurospora histone H3 have varied effects on DNA methylation.New insights into checkpoint kinase 1 in the DNA damage response signaling network.Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivoProtein phosphatase 1γ is responsible for dephosphorylation of histone H3 at Thr 11 after DNA damage.Histone phosphorylation: a chromatin modification involved in diverse nuclear events.Histone H3 phosphorylation in GBM: a new rational to guide the use of kinase inhibitors in anti-GBM therapy.CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells.DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B.The fork and the kinase: a DNA replication tale from a CHK1 perspective.Epigenetic mechanisms and genome stability.Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma.Targeted mutations in the ATR pathway define agent-specific requirements for cancer cell growth and survival
P2860
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P2860
Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Chk1 is a histone H3 threonine ...... ced transcriptional repression
@ast
Chk1 is a histone H3 threonine ...... ced transcriptional repression
@en
Chk1 is a histone H3 threonine ...... ced transcriptional repression
@en-gb
Chk1 is a histone H3 threonine ...... ced transcriptional repression
@nl
type
label
Chk1 is a histone H3 threonine ...... ced transcriptional repression
@ast
Chk1 is a histone H3 threonine ...... ced transcriptional repression
@en
Chk1 is a histone H3 threonine ...... ced transcriptional repression
@en-gb
Chk1 is a histone H3 threonine ...... ced transcriptional repression
@nl
prefLabel
Chk1 is a histone H3 threonine ...... ced transcriptional repression
@ast
Chk1 is a histone H3 threonine ...... ced transcriptional repression
@en
Chk1 is a histone H3 threonine ...... ced transcriptional repression
@en-gb
Chk1 is a histone H3 threonine ...... ced transcriptional repression
@nl
P2093
P921
P3181
P1433
P1476
Chk1 is a histone H3 threonine ...... ced transcriptional repression
@en
P2093
Doaa H Zineldeen
Hideaki Tagami
Hiroyuki Niida
Hiroyuki Saito
Makoto Nakanishi
Masafumi Tanaka
Midori Shimada
P304
P3181
P356
10.1016/J.CELL.2007.12.013
P407
P577
2008-01-25T00:00:00Z