DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate - Test2 - elhamkhani - TriplyDB

DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate

DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate

http://www.wikidata.org/entity/Q24309978

about

Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3 Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2 Reduced heparan sulfate accumulation in enterocytes contributes to protein-losing enteropathy in a congenital disorder of glycosylation Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8 O Mannosylation of alpha-dystroglycan is essential for lymphocytic choriomeningitis virus receptor function DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3 The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component.PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER.Deficiency of dolichol-phosphate-mannose synthase-1 causes congenital disorder of glycosylation type Ie Dolichol phosphate mannose synthase (DPM1) mutations define congenital disorder of glycosylation Ie (CDG-Ie)Deficiency of Dol-P-Man synthase subunit DPM3 bridges the congenital disorders of glycosylation with the dystroglycanopathies The potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophy Biosynthesis and deficiencies of glycosylphosphatidylinositol N-glycans in cell survival and death: cross-talk between glycosyltransferases Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p.Structural studies and mechanism of Saccharomyces cerevisiae dolichyl-phosphate-mannose synthase: insights into the initial step of synthesis of dolichyl-phosphate-linked oligosaccharide chains in membranes of endoplasmic reticulum.PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor.Genes for glycosylphosphatidylinositol toxin biosynthesis in Plasmodium falciparum.Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol PGAP2 is essential for correct processing and stable expression of GPI-anchored proteins GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis The ins(ide) and out(side) of dolichyl phosphate biosynthesis and recycling in the endoplasmic reticulum Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells.Biosynthesis of glycosylphosphatidylinositols in mammals and unicellular microbes.Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dolicholphosphate-mannose synthase gene deletion mutants.Update and perspectives on congenital disorders of glycosylation.Congenital disorders of glycosylation: glycosylation defects in man and biological models for their study.Glycosyltransferase complexes in eukaryotes: long-known, prevalent but still unrecognized.Mutational and functional analysis of Large in a novel CHO glycosylation mutant.Genome-Wide Screening of Genes Required for Glycosylphosphatidylinositol Biosynthesis.Isolation of Endoplasmic Reticulum, Mitochondria, and Mitochondria-Associated Membrane and Detergent Resistant Membrane Fractions from Transfected Cells and from Human Cytomegalovirus-Infected Primary Fibroblasts Novel Citronellyl-Based Photoprobes Designed to Identify ER Proteins Interacting with Dolichyl Phosphate in Yeast and Mammalian Cells.Genetic and immunohistochemical analysis of HSPA5 in mouse and human retinas.The cell surface proteome of Entamoeba histolytica.Protein glycosylation in Candida.N-linked protein glycosylation in the endoplasmic reticulum.Requirement of N-glycan on GPI-anchored proteins for efficient binding of aerolysin but not Clostridium septicum alpha-toxin.

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P2860

DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate

http://www.wikidata.org/entity/Q24309978

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1998 nî lūn-bûn

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1998 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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1998 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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The EMBO Journal

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DPM2 regulates biosynthesis of ...... binding of dolichol phosphate

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Kinoshita T

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Maeda Y

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Ohishi K

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Tomita S

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Watanabe R

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P2860

Isolation and characterization of the human chromosomal gene for polypeptide chain elongation factor-1 alpha

PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum

A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells

Genomic sequencing

Human and Saccharomyces cerevisiae dolichol phosphate mannose synthases represent two classes of the enzyme, but both function in Schizosaccharomyces pombe

Basic local alignment search tool

A simple method for displaying the hydropathic character of a protein

Dolichol phosphate mannose synthase is required in vivo for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and N glycosylation of protein in Saccharomyces cerevisiae

Cloning and sequencing of the yeast gene for dolichol phosphate mannose synthase, an essential protein.

Assembly of asparagine-linked oligosaccharides

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4920-4929

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10.1093/EMBOJ/17.17.4920

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17

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P921

Dolichyl-phosphate mannosyltransferase subunit 1, catalytic

CD59 molecule (CD59 blood group)

P932

1170821

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