Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication - Test2 - elhamkhani - TriplyDB

Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication

Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication

http://www.wikidata.org/entity/Q24310689

about

Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with PYM to enhance translation of viral intronless mRNAs Activation of DNA Damage Response Induced by the Kaposi's Sarcoma-Associated Herpes Virus The KSHV RNA regulator ORF57: target specificity and its role in the viral life cycle Structural Basis for the Recognition of Cellular mRNA Export Factor REF by Herpes Viral Proteins HSV-1 ICP27 and HVS ORF57 Competitive and Cooperative Interactions Mediate RNA Transfer from Herpesvirus Saimiri ORF57 to the Mammalian Export Adaptor ALYREF The role of TREX in gene expression and disease Targeting the ATP-dependent formation of herpesvirus ribonucleoprotein particle assembly as an antiviral approach Highly pathogenic avian influenza virus nucleoprotein interacts with TREX complex adaptor protein Aly/REF The cellular DExD/H-box RNA-helicases UAP56 and URH49 exhibit a CRM1-independent nucleocytoplasmic shuttling activity.Varicella-zoster virus IE4 protein interacts with SR proteins and exports mRNAs through the TAP/NXF1 pathway.Kaposi's sarcoma-associated herpesvirus ORF57 protein binds and protects a nuclear noncoding RNA from cellular RNA decay pathways.ICP27 phosphorylation site mutants display altered functional interactions with cellular export factors Aly/REF and TAP/NXF1 but are able to bind herpes simplex virus 1 RNA An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export.A viral nuclear noncoding RNA binds re-localized poly(A) binding protein and is required for late KSHV gene expression.Requirement of UAP56, URH49, RBM15, and OTT3 in the expression of Kaposi sarcoma-associated herpesvirus ORF57.Attenuation of the suppressive activity of cellular splicing factor SRSF3 by Kaposi sarcoma-associated herpesvirus ORF57 protein is required for RNA splicing Kaposi's sarcoma-associated herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59.Individual influenza A virus mRNAs show differential dependence on cellular NXF1/TAP for their nuclear export.Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppression Identification of the physiological gene targets of the essential lytic replicative Kaposi's sarcoma-associated herpesvirus ORF57 protein Stability of structured Kaposi's sarcoma-associated herpesvirus ORF57 protein is regulated by protein phosphorylation and homodimerization.KSHV ORF57, a protein of many faces A novel mechanism inducing genome instability in Kaposi's sarcoma-associated herpesvirus infected cells.HITS-CLIP analysis uncovers a link between the Kaposi's sarcoma-associated herpesvirus ORF57 protein and host pre-mRNA metabolism Selective recruitment of nuclear factors to productively replicating herpes simplex virus genomes.Structure of the C-Terminal Domain of the Multifunctional ICP27 Protein from Herpes Simplex Virus 1 Epstein-Barr virus protein EB2 stimulates cytoplasmic mRNA accumulation by counteracting the deleterious effects of SRp20 on viral mRNAs Binding of cellular export factor REF/Aly by Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is not required for efficient KSHV lytic replication.Kaposi's sarcoma-associated herpesvirus ORF57 is not a bona fide export factor.Interplay between polyadenylate-binding protein 1 and Kaposi's sarcoma-associated herpesvirus ORF57 in accumulation of polyadenylated nuclear RNA, a viral long noncoding RNA.The interaction of the cellular export adaptor protein Aly/REF with ICP27 contributes to the efficiency of herpes simplex virus 1 mRNA export.The cellular RNA export receptor TAP/NXF1 is required for ICP27-mediated export of herpes simplex virus 1 RNA, but the TREX complex adaptor protein Aly/REF appears to be dispensable.Epstein-Barr virus protein EB2 contains an N-terminal transferable nuclear export signal that promotes nucleocytoplasmic export by directly binding TAP/NXF1.Virus-mediated mRNA decay by hyperadenylation.Nucleolar proteomics and viral infection.The many roles of the highly interactive HSV protein ICP27, a key regulator of infection.KSHV Rta Promoter Specification and Viral Reactivation.The Kaposi's Sarcoma-Associated Herpesvirus ORF57 Protein and Its Multiple Roles in mRNA Biogenesis.Nuclear imprisonment: viral strategies to arrest host mRNA nuclear export.Kaposi's sarcoma-associated herpesvirus ORF57 protein: exploiting all stages of viral mRNA processing.

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Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication

http://www.wikidata.org/entity/Q24310689

description

2008 nî lūn-bûn

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2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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Recruitment of the complete hT ...... r export and virus replication

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JOURNAL.PPAT.1000194

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Recruitment of the complete hT ...... r export and virus replication

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Kevin J Colgan

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Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20

Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor

The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA

PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs

Recruitment of the human TREX complex to mRNA during splicing

Human mRNA export machinery recruited to the 5' end of mRNA

The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

Splicing enhances translation in mammalian cells: an additional function of the exon junction complex

Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA

Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly

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10.1371/JOURNAL.PPAT.1000194

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10

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Adrian Whitehouse

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2008-10-01T00:00:00Z

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18974867

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Arginine methylation regulates the function of a key herpesvirus nucleocytoplasmic shuttle protein

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viral mRNA export from host cell nucleus

DExD-box helicase 39B

Aly/REF export factor

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2569588

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journal.ppat.1000194