Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies - Test2 - elhamkhani - TriplyDB

Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies

Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies

http://www.wikidata.org/entity/Q24311314

about

A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor Novel alternative splicing and nuclear localization of human RGS12 gene products The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor The promyelocytic leukemia protein interacts with Sp1 and inhibits its transactivation of the epidermal growth factor receptor promoter The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions PLZF is a negative regulator of retinoic acid receptor transcriptional activity Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene Targeting of leukemia-initiating cells in acute promyelocytic leukemia Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF PLZF induces megakaryocytic development, activates Tpo receptor expression and interacts with GATA1 protein Identification of three major sentrinization sites in PML PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient.Human endogenous retrovirus protein cORF supports cell transformation and associates with the promyelocytic leukemia zinc finger protein.The pathogenesis of acute promyelocytic leukaemia: evaluation of the role of molecular diagnosis and monitoring in the management of the disease.Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein.Genetic-epigenetic dysregulation of thymic TSH receptor gene expression triggers thyroid autoimmunity Retinoic acid receptor alpha (RAralpha) Mutations in Human Leukemia.Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.Common themes in the pathogenesis of acute myeloid leukemia.Immunohistochemical detection of promyelocytic leukemia zinc finger and histone 1.5 in uterine leiomyosarcoma and leiomyoma.Translocations of the RARalpha gene in acute promyelocytic leukemia.The theory of APL.Pathways of retinoic acid- or arsenic trioxide-induced PML/RARalpha catabolism, role of oncogene degradation in disease remission.Specific deficiency of Plzf paralog, Zbtb20, in Sertoli cells does not affect spermatogenesis and fertility in mice.NLRP7, Involved in Hydatidiform Molar Pregnancy (HYDM1), Interacts with the Transcriptional Repressor ZBTB16.Acute promyelocytic leukemia: PML/RARalpha and the leukemic stem cell.POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and function The promyelocytic leukemia zinc finger protein: two decades of molecular oncology RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia.The promyelocytic leukemia zinc finger protein down-regulates apoptosis and expression of the proapoptotic BID protein in lymphocytes Role of LRF/Pokemon in lineage fate decisions.Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins.Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity Biography of Zhu Chen.

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P2860

Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies

http://www.wikidata.org/entity/Q24311314

description

1997 nî lūn-bûn

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1997 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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1997 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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1997年の論文

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1997年論文

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1997年論文

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1997年論文

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1997年論文

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1997年论文

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P2860

Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment

Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein

Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors

Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1

KAP-1, a novel corepressor for the highly conserved KRAB repression domain

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

PML, a growth suppressor disrupted in acute promyelocytic leukemia

Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins

Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia

A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins

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