CYP2D6-CYP2C9 protein-protein interactions and isoform-selective effects on substrate binding and catalysis
about
The Role of Protein-Protein and Protein-Membrane Interactions on P450 FunctionCYP2C9 genotype vs. metabolic phenotype for individual drug dosing--a correlation analysis using flurbiprofen as probe drugCYP2C9-CYP3A4 protein-protein interactions: role of the hydrophobic N terminus.Role of protein-protein interactions in cytochrome P450-mediated drug metabolism and toxicityCYP2C8 exists as a dimer in natural membranes.Altered CYP2C9 activity following modulation of CYP3A4 levels in human hepatocytes: an example of protein-protein interactions.Cytochrome P450 system proteins reside in different regions of the endoplasmic reticulum.Interactions among cytochromes P450 in microsomal membranes: oligomerization of cytochromes P450 3A4, 3A5, and 2E1 and its functional consequencesDevelopment of an in vitro system with human liver microsomes for phenotyping of CYP2C9 genetic polymorphisms with a mechanism-based inactivatorIdentification of cytochrome P450 2C2 protein complexes in mouse liver.Effect of homomeric P450-P450 complexes on P450 function.Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism.Nanoscale electron transport measurements of immobilized cytochrome P450 proteins.Immobilized Cytochrome P450 for Monitoring of P450-P450 Interactions and MetabolismInteractions between cytochromes P450 2B4 (CYP2B4) and 1A2 (CYP1A2) lead to alterations in toluene disposition and P450 uncouplingCorrelating structure and function of drug-metabolizing enzymes: progress and ongoing challenges.Physical Studies of P450-P450 Interactions: Predicting Quaternary Structures of P450 Complexes in Membranes from Their X-ray Crystal Structures.Microsomal monooxygenase as a multienzyme system: the role of P450-P450 interactions.Formation of P450 · P450 complexes and their effect on P450 functionThe functional effects of physical interactions involving cytochromes P450: putative mechanisms of action and the extent of these effects in biological membranes.Single-molecule fluorescence spectroscopy using phospholipid bilayer nanodiscs.Extensive protein interactions involving cytochrome P450 3A4: a possible contributor to the formation of a metabolosome.Characterization of interactions among CYP1A2, CYP2B4, and NADPH-cytochrome P450 reductase: Identification of specific protein complexes.Toward a systems approach to the human cytochrome P450 ensemble: interactions between CYP2D6 and CYP2E1 and their functional consequences.
P2860
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P2860
CYP2D6-CYP2C9 protein-protein interactions and isoform-selective effects on substrate binding and catalysis
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
CYP2D6-CYP2C9 protein-protein ...... ubstrate binding and catalysis
@ast
CYP2D6-CYP2C9 protein-protein ...... ubstrate binding and catalysis
@en
CYP2D6-CYP2C9 protein-protein ...... ubstrate binding and catalysis
@en-gb
CYP2D6-CYP2C9 protein-protein ...... ubstrate binding and catalysis
@nl
type
label
CYP2D6-CYP2C9 protein-protein ...... ubstrate binding and catalysis
@ast
CYP2D6-CYP2C9 protein-protein ...... ubstrate binding and catalysis
@en
CYP2D6-CYP2C9 protein-protein ...... ubstrate binding and catalysis
@en-gb
CYP2D6-CYP2C9 protein-protein ...... ubstrate binding and catalysis
@nl
prefLabel
CYP2D6-CYP2C9 protein-protein ...... ubstrate binding and catalysis
@ast
CYP2D6-CYP2C9 protein-protein ...... ubstrate binding and catalysis
@en
CYP2D6-CYP2C9 protein-protein ...... ubstrate binding and catalysis
@en-gb
CYP2D6-CYP2C9 protein-protein ...... ubstrate binding and catalysis
@nl
P2093
P2860
P921
P356
P1476
CYP2D6-CYP2C9 protein-protein ...... ubstrate binding and catalysis
@en
P2093
Charles W Locuson
Michael Low
Murali Subramanian
Timothy S Tracy
P2860
P304
P356
10.1124/DMD.109.026500
P407
P577
2009-08-01T00:00:00Z