Identification of cholesterol-regulating genes by targeted RNAi screening
about
RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory functionTargeted disruption of steroidogenic acute regulatory protein D4 leads to modest weight reduction and minor alterations in lipid metabolismGenomic screening with RNAi: results and challengesThe combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescueRHOA is a modulator of the cholesterol-lowering effects of statinFluorescent Sterols and Cholesteryl Esters as Probes for Intracellular Cholesterol TransportGenome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells.Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors.Investigating the effects of statins on cellular lipid metabolism using a yeast expression system.Automated microscopy for high-content RNAi screeningEndocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells.Identification of the gene that codes for the σ2 receptor.Improvement in lipid and protein trafficking in Niemann-Pick C1 cells by correction of a secondary enzyme defect.Differential gene expression in liver and small intestine from lactating rats compared to age-matched virgin controls detects increased mRNA of cholesterol biosynthetic genes.TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic diseaseDistribution and functions of sterols and sphingolipids.Systematic cell-based phenotyping of missense alleles empowers rare variant association studies: a case for LDLR and myocardial infarction.A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells.Niemann-Pick Type C disease: characterizing lipid levels in patients with variant lysosomal cholesterol storage.Impact of Statins on Gene Expression in Human Lung Tissues.Dynamics of short-term gene expression profiling in liver following thermal injury.MicroRNA-27b is a regulatory hub in lipid metabolism and is altered in dyslipidemiaCharacterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding.Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's beenFunctional genomic and epidemiological studies reveal novel genes regulating cholesterol metabolism.Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) Is a Novel Nutritional Therapeutic Target for Hyperlipidemia, Non-Alcoholic Fatty Liver Disease, and Atherosclerosis.Quantitative Co-Localization and Pattern Analysis of Endo-Lysosomal Cargo in Subcellular Image Cytometry and Validation on Synthetic Image Sets.Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice.Prohibitin is a cholesterol-sensitive regulator of cell cycle transit.Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells.Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease.Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.Hepatic iron loading in mice increases cholesterol biosynthesis.N-Myc Downstream-Regulated Gene 1 Restricts Hepatitis C Virus Propagation by Regulating Lipid Droplet Biogenesis and Viral Assembly.The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission.Cloning the sigma2 receptor: Wandering 40 years to find an identity.The sigma-1 receptor as a regulator of dopamine neurotransmission: A potential therapeutic target for methamphetamine addiction.Introduction to Sigma Proteins: Evolution of the Concept of Sigma Receptors.RNA interference against TMEM97 inhibits cell proliferation, migration, and invasion in glioma cells.Identification of stable reference genes for quantitative PCR in koalas.
P2860
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P2860
Identification of cholesterol-regulating genes by targeted RNAi screening
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Identification of cholesterol-regulating genes by targeted RNAi screening
@ast
Identification of cholesterol-regulating genes by targeted RNAi screening
@en
Identification of cholesterol-regulating genes by targeted RNAi screening
@en-gb
Identification of cholesterol-regulating genes by targeted RNAi screening
@nl
type
label
Identification of cholesterol-regulating genes by targeted RNAi screening
@ast
Identification of cholesterol-regulating genes by targeted RNAi screening
@en
Identification of cholesterol-regulating genes by targeted RNAi screening
@en-gb
Identification of cholesterol-regulating genes by targeted RNAi screening
@nl
prefLabel
Identification of cholesterol-regulating genes by targeted RNAi screening
@ast
Identification of cholesterol-regulating genes by targeted RNAi screening
@en
Identification of cholesterol-regulating genes by targeted RNAi screening
@en-gb
Identification of cholesterol-regulating genes by targeted RNAi screening
@nl
P2093
P3181
P1433
P1476
Identification of cholesterol-regulating genes by targeted RNAi screening
@en
P2093
Daniel Gilbert
Dorothee Erz
Fabian Bartz
Heiko Runz
Luise Kern
Martina Muckenthaler
Mingang Zhu
Till Meinhof
Ute Wirkner
P3181
P356
10.1016/J.CMET.2009.05.009
P407
P577
2009-07-01T00:00:00Z