A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity
about
The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIISCnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiationThe PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesisLessons from genome-wide studies: an integrated definition of the coactivator function of histone acetyl transferasesGenomic screening with RNAi: results and challengesAcute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identityRole of Oct4 in the early embryo developmentThe transcriptional regulation of pluripotencyTranscriptional regulation by coactivators in embryonic stem cellsCdc73 Subunit of Paf1 Complex Contains C-terminal Ras-like Domain That Promotes Association of Paf1 Complex with ChromatinStructural insights into Paf1 complex assembly and histone bindingEffects of the Paf1 complex and histone modifications on snoRNA 3'-end formation reveal broad and locus-specific regulation.The RNA polymerase-associated factor 1 complex (Paf1C) directly increases the elongation rate of RNA polymerase I and is required for efficient regulation of rRNA synthesis.An expanded Oct4 interaction network: implications for stem cell biology, development, and diseaseA Myc network accounts for similarities between embryonic stem and cancer cell transcription programsCTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation developmentAn evolutionarily conserved long noncoding RNA TUNA controls pluripotency and neural lineage commitmentThe THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogrammingZfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogrammingControl of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genesLIF-dependent signaling: new pieces in the LegoControl of the embryonic stem cell stateMaster transcription factors and mediator establish super-enhancers at key cell identity genesThe PAF1 complex differentially regulates cardiomyocyte specification.The Paf1 complex represses small-RNA-mediated epigenetic gene silencing.ChIP-Array 2: integrating multiple omics data to construct gene regulatory networksSetd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation.rtfA controls development, secondary metabolism, and virulence in Aspergillus fumigatusNANOG reporter cell lines generated by gene targeting in human embryonic stem cells.SVM classifier to predict genes important for self-renewal and pluripotency of mouse embryonic stem cells.H2B ubiquitylation promotes RNA Pol II processivity via PAF1 and pTEFbSmall molecules and stem cells. Potency and lineage commitment: the new quest for the fountain of youth.Totipotency in the mouse.PTBP1 is required for embryonic development before gastrulation.Prioritizing candidate disease genes by network-based boosting of genome-wide association data.RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity.RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cellsNovel role of pancreatic differentiation 2 in facilitating self-renewal and drug resistance of pancreatic cancer stem cells.Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cellsGermline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour.
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P2860
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A genome-scale RNAi screen for ...... r embryonic stem cell identity
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A genome-scale RNAi screen for ...... r embryonic stem cell identity
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A genome-scale RNAi screen for ...... r embryonic stem cell identity
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A genome-scale RNAi screen for ...... r embryonic stem cell identity
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A genome-scale RNAi screen for ...... r embryonic stem cell identity
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A genome-scale RNAi screen for ...... r embryonic stem cell identity
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A genome-scale RNAi screen for ...... r embryonic stem cell identity
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A genome-scale RNAi screen for ...... r embryonic stem cell identity
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A genome-scale RNAi screen for ...... r embryonic stem cell identity
@ast
A genome-scale RNAi screen for ...... r embryonic stem cell identity
@en
A genome-scale RNAi screen for ...... r embryonic stem cell identity
@en-gb
A genome-scale RNAi screen for ...... r embryonic stem cell identity
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A genome-scale RNAi screen for ...... r embryonic stem cell identity
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P2093
A Francis Stewart
Andrej Shevchenko
Anja Nitzsche
Anne-Kristin Heninger
Antonio Caldarelli
Herbert Schulz
Ingrid de Vries
Juergen Hescheler
Konstantinos Anastassiadis
P304
P3181
P356
10.1016/J.STEM.2009.03.009
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2009-05-08T00:00:00Z