Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity
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Induction and function of type I and III interferon in response to viral infectionPhysiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway ModulationsEmerging therapies for systemic lupus erythematosus--focus on targeting interferon-alphaInterleukin-1 receptor-associated kinase 2- and protein kinase D1-dependent regulation of IRAK-monocyte expression by CpG DNAMycoepoxydiene inhibits lipopolysaccharide-induced inflammatory responses through the suppression of TRAF6 polyubiquitination [corrected]Zinc finger protein 64 promotes Toll-like receptor-triggered proinflammatory and type I interferon production in macrophages by enhancing p65 subunit activationHighlights of the advances in basic immunology in 2011.Pin1-Targeted Therapy for Systemic Lupus ErythematosusInterferon regulatory factor 6 differentially regulates Toll-like receptor 2-dependent chemokine gene expression in epithelial cells.B-cell activating factor-receptor specific activation of tumor necrosis factor receptor associated factor 6 and the phosphatidyl inositol 3-kinase pathway in lymphoma B cellsThe prolyl isomerase Pin1 modulates development of CD8+ cDC in mice.Toll-like receptor 7-mediated type I interferon signaling prevents cholestasis- and hepatotoxin-induced liver fibrosis.Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α.Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase.Deciphering transcriptome profiles of peripheral blood mononuclear cells in response to PRRSV vaccination in pigs.A sibship with duplication of Xq28 inherited from the mother; genomic characterization and clinical outcomes.Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent modelComplete thermodynamic and kinetic characterization of the isomer-specific interaction between Pin1-WW domain and the amyloid precursor protein cytoplasmic tail phosphorylated at Thr668.Negative regulatory approaches to the attenuation of Toll-like receptor signaling.Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease.Disabled-2 is a negative immune regulator of lipopolysaccharide-stimulated Toll-like receptor 4 internalization and signaling.Regulation of TLR7/9 signaling in plasmacytoid dendritic cells.Regulation of Toll-like receptor signaling pathways in innate immune responses.Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.Preconditioning with recombinant high-mobility group box 1 induces ischemic tolerance in a rat model of focal cerebral ischemia-reperfusion.The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target.The role of Pin1 in the development and treatment of cancer.Pin1 is overexpressed and correlates with poor prognosis in gastric cancer.Pin1 promotes GR transactivation by enhancing recruitment to target genes.Pin1 interacts with the Epstein-Barr virus DNA polymerase catalytic subunit and regulates viral DNA replication.Neighboring phosphoSer-Pro motifs in the undefined domain of IRAK1 impart bivalent advantage for Pin1 binding.Overexpression of methyl-CpG binding protein 2 impairs T(H)1 responses.The pellino e3 ubiquitin ligases recognize specific phosphothreonine motifs and have distinct substrate specificities.Cellular FLIP long isoform (cFLIPL)-IKKα interactions inhibit IRF7 activation, representing a new cellular strategy to inhibit IFNα expression.The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation.Pin1 promotes prostate cancer cell proliferation and migration through activation of Wnt/β-catenin signaling.TPA-induced cell transformation provokes a complex formation between Pin1 and 90 kDa ribosomal protein S6 kinase 2.Prolyl isomerase Pin1: a promoter of cancer and a target for therapy
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P2860
Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Essential role for the prolyl ...... I interferon-mediated immunity
@ast
Essential role for the prolyl ...... I interferon-mediated immunity
@en
Essential role for the prolyl ...... I interferon-mediated immunity
@en-gb
Essential role for the prolyl ...... I interferon-mediated immunity
@nl
type
label
Essential role for the prolyl ...... I interferon-mediated immunity
@ast
Essential role for the prolyl ...... I interferon-mediated immunity
@en
Essential role for the prolyl ...... I interferon-mediated immunity
@en-gb
Essential role for the prolyl ...... I interferon-mediated immunity
@nl
prefLabel
Essential role for the prolyl ...... I interferon-mediated immunity
@ast
Essential role for the prolyl ...... I interferon-mediated immunity
@en
Essential role for the prolyl ...... I interferon-mediated immunity
@en-gb
Essential role for the prolyl ...... I interferon-mediated immunity
@nl
P2093
P2860
P3181
P356
P1433
P1476
Essential role for the prolyl ...... I interferon-mediated immunity
@en
P2093
Adrian Tun-Kyi
Alex Greenwood
Elliot Israel
George C Tsokos
John M Asara
Kate Fitzgerald
Kun Ping Lu
Linda K Nicholson
Mark Exley
P2860
P304
P3181
P356
10.1038/NI.2069
P407
P577
2011-08-01T00:00:00Z