Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation.
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Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activationHuman CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleedingThe integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell.Inherited platelet disorders: toward DNA-based diagnosisConcerning immune synapses: a spatiotemporal timelineGenomic landscape of megakaryopoiesis and platelet function defectsT Lymphocyte Migration: An Action Movie Starring the Actin and Associated Actors.The regulatory role of serum response factor pathway in neutrophil inflammatory responseKindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells.The Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin ActivationStructural and Functional Characterization of the Kindlin-1 Pleckstrin Homology DomainStructures and Interaction Analyses of Integrin M 2 Cytoplasmic TailsMembrane Binding of the N-Terminal Ubiquitin-Like Domain of kindlin-2 Is Crucial for Its Regulation of Integrin ActivationChemokines, selectins and intracellular calcium flux: temporal and spatial cues for leukocyte arrestRegulation of cell adhesion and migration by Kindlin-3 cleavage by calpainNeutrophil cell surface receptors and their intracellular signal transduction pathways.Diverse functions of kindlin/fermitin proteins during embryonic development in Xenopus laevis.Kindlin-1 Is required for RhoGTPase-mediated lamellipodia formation in keratinocytesThe integrin coactivator kindlin-2 plays a critical role in angiogenesis in mice and zebrafishDistinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation.A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes.Chronic lymphocytic leukemia cells induce defective LFA-1-directed T-cell motility by altering Rho GTPase signaling that is reversible with lenalidomide.Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells.NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization.Integrin-Kindlin3 requirements for microglial motility in vivo are distinct from those for macrophages.Glanzmann thrombasthenia: state of the art and future directions.Naïve T cells re-distribute to the lungs of selectin ligand deficient mice.ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.The final steps of integrin activation: the end gameTyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation.Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice.Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activationSpatial coordination of kindlin-2 with talin head domain in interaction with integrin β cytoplasmic tailsA role of kindlin-3 in integrin αMβ2 outside-in signaling and the Syk-Vav1-Rac1/Cdc42 signaling axisA novel tumor suppressor function of Kindlin-3 in solid cancer.Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype.Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions.Molecular architecture and function of matrix adhesions.Emergence and subsequent functional specialization of kindlins during evolution of cell adhesiveness.Site-specific phosphorylation of kindlin-3 protein regulates its capacity to control cellular responses mediated by integrin αIIbβ3.
P2860
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P1343
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P2860
Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation.
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Leukocyte adhesion deficiency- ...... affecting integrin activation
@nl
Leukocyte adhesion deficiency- ...... affecting integrin activation.
@ast
Leukocyte adhesion deficiency- ...... affecting integrin activation.
@en
Leukocyte adhesion deficiency- ...... affecting integrin activation.
@en-gb
type
label
Leukocyte adhesion deficiency- ...... affecting integrin activation
@nl
Leukocyte adhesion deficiency- ...... affecting integrin activation.
@ast
Leukocyte adhesion deficiency- ...... affecting integrin activation.
@en
Leukocyte adhesion deficiency- ...... affecting integrin activation.
@en-gb
prefLabel
Leukocyte adhesion deficiency- ...... affecting integrin activation
@nl
Leukocyte adhesion deficiency- ...... affecting integrin activation.
@ast
Leukocyte adhesion deficiency- ...... affecting integrin activation.
@en
Leukocyte adhesion deficiency- ...... affecting integrin activation.
@en-gb
P2093
P2860
P50
P3181
P356
P1433
P1476
Leukocyte adhesion deficiency- ...... affecting integrin activation.
@en
P2093
Alison McDowall
Ayse Metin
Irene Patzak
Kimberley Howarth
Lena Svensson
Markus Moser
Mike Fried
Nancy Hogg
P2860
P2888
P304
P3181
P356
10.1038/NM.1931
P407
P577
2009-02-22T00:00:00Z
P5875
P6179
1015371728