Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3
about
A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 proteinCharacterization of a second member of the subfamily of calcium-binding mitochondrial carriers expressed in human non-excitable tissuesBehavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient miceThe calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membraneThe Ca2+-binding protein ALG-2 is recruited to endoplasmic reticulum exit sites by Sec31A and stabilizes the localization of Sec31ADAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell deathStructure and physiological function of calpainsStructure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell deathThe penta-EF-hand protein ALG-2 interacts directly with the ESCRT-I component TSG101, and Ca2+-dependently co-localizes to aberrant endosomes with dominant-negative AAA ATPase SKD1/Vps4BMolecular mechanisms of calcium and magnesium binding to parvalbumin.YPXL/I is a protein interaction motif recognized by aspergillus PalA and its human homologue, AIP1/AlixA rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and AbetaRORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cellsInteraction of presenilins with the filamin family of actin-binding proteinsPhosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosisMapping common deleted regions on 5p15 in cervical carcinoma and their occurrence in precancerous lesions.Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays.Multifaceted Roles of ALG-2 in Ca(2+)-Regulated Membrane TraffickingCrystallization and X-ray diffraction analysis of N-terminally truncated human ALG-2Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2DeltaGF122) and structural roles of F122 in target recognitionBro1 coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4 to endosomes.The yeast penta-EF protein Pef1p is involved in cation-dependent budding and cell polarization.Yeast PalA/AIP1/Alix homolog Rim20p associates with a PEST-like region and is required for its proteolytic cleavage.Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-cateninHp95 promotes anoikis and inhibits tumorigenicity of HeLa cellsInteraction of ALG-2 with ASK1 influences ASK1 localization and subsequent JNK activationBoth the N-terminal fragment and the protein-protein interaction domain (PDZ domain) are required for the pro-apoptotic activity of presenilin-associated protein PSAPFunctional dynamics of the hydrophobic cleft in the N-domain of calmodulinPresenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiencyProfiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamusGranulocyte function in grancalcin-deficient miceStructural and Functional Study of Apoptosis-linked Gene-2·Heme-binding Protein 2 Interactions in HIV-1 ProductionStructural analysis of the complex between penta-EF-hand ALG-2 protein and Sec31A peptide reveals a novel target recognition mechanism of ALG-2Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activitiesGenomic markers for malignant progression in pulmonary adenocarcinoma with bronchioloalveolar featuresEndogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix.ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex.Calcium-dependent interaction of annexin I with annexin II and mapping of the interaction sites.Genetic synthetic lethality screen at the single gene level in cultured human cells.Inhibition of glucocorticoid-induced apoptosis by the expression of antisense gene of mitochondrial ATPase subunit 6(1).
P2860
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P2860
Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3
description
1996 nî lūn-bûn
@nan
1996 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Interfering with apoptosis: Ca ...... Alzheimer's disease gene ALG-3
@ast
Interfering with apoptosis: Ca ...... Alzheimer's disease gene ALG-3
@en
Interfering with apoptosis: Ca ...... Alzheimer's disease gene ALG-3
@en-gb
Interfering with apoptosis: Ca ...... Alzheimer's disease gene ALG-3
@nl
type
label
Interfering with apoptosis: Ca ...... Alzheimer's disease gene ALG-3
@ast
Interfering with apoptosis: Ca ...... Alzheimer's disease gene ALG-3
@en
Interfering with apoptosis: Ca ...... Alzheimer's disease gene ALG-3
@en-gb
Interfering with apoptosis: Ca ...... Alzheimer's disease gene ALG-3
@nl
prefLabel
Interfering with apoptosis: Ca ...... Alzheimer's disease gene ALG-3
@ast
Interfering with apoptosis: Ca ...... Alzheimer's disease gene ALG-3
@en
Interfering with apoptosis: Ca ...... Alzheimer's disease gene ALG-3
@en-gb
Interfering with apoptosis: Ca ...... Alzheimer's disease gene ALG-3
@nl
P2093
P921
P3181
P1433
P1476
Interfering with apoptosis: Ca ...... Alzheimer's disease gene ALG-3
@en
P2093
P3181
P356
10.1126/SCIENCE.271.5248.521
P407
P577
1996-01-26T00:00:00Z