MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks
about
The E3 ligase RNF8 regulates KU80 removal and NHEJ repairBMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repairChoreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear ArchitectureRole of Deubiquitinating Enzymes in DNA RepairThe deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cellsThe DNA Damage Response: Making It Safe to Play with KnivesA BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responsesDouble strand break repair functions of histone H2AXMERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signalingCommon variants at 19p13 are associated with susceptibility to ovarian cancer.Quantitative imaging of single mRNA splice variants in living cellsSpecificity of the BRISC deubiquitinating enzyme is not due to selective binding to Lys63-linked polyubiquitin.Mutation screening of the MERIT40 gene encoding a novel BRCA1 and RAP80 interacting protein in breast cancer familiesMutations in the BRCT binding site of BRCA1 result in hyper-recombinationMutation screening of the RNF8, UBC13 and MMS2 genes in Northern Finnish breast cancer families.Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 fociDifferential regulation of JAMM domain deubiquitinating enzyme activity within the RAP80 complex.The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartmentsLoss of BRCA1-A complex function in RAP80 null tumor cellsBRCC36A is epistatic to BRCA1 in DNA crosslink repair and homologous recombination in Arabidopsis thalianaNBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexesRAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci.A Genome-Wide Association Study Suggests Novel Loci Associated with a Schizophrenia-Related Brain-Based PhenotypeThe BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection.The role of BRCA1 in DNA damage response.Loss of BRCC3 deubiquitinating enzyme leads to abnormal angiogenesis and is associated with syndromic moyamoya.A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general populationBRCA1 A‐complex fine tunes repair functions of BRCA1.Two-layer modular analysis of gene and protein networks in breast cancer.MERIT40 Is an Akt Substrate that Promotes Resolution of DNA Damage Induced by Chemotherapy.BRCA1 tumor suppressor network: focusing on its tail.Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.19p13.1 is a triple-negative-specific breast cancer susceptibility locus.Common breast cancer susceptibility loci are associated with triple-negative breast cancer.Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs.RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivoMERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.Expression of the BRCA1 complex member BRE predicts disease free survival in breast cancer.
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MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
MERIT40 controls BRCA1-Rap80 c ...... nt to DNA double-strand breaks
@ast
MERIT40 controls BRCA1-Rap80 c ...... nt to DNA double-strand breaks
@en
MERIT40 controls BRCA1-Rap80 c ...... nt to DNA double-strand breaks
@en-gb
MERIT40 controls BRCA1-Rap80 c ...... nt to DNA double-strand breaks
@nl
type
label
MERIT40 controls BRCA1-Rap80 c ...... nt to DNA double-strand breaks
@ast
MERIT40 controls BRCA1-Rap80 c ...... nt to DNA double-strand breaks
@en
MERIT40 controls BRCA1-Rap80 c ...... nt to DNA double-strand breaks
@en-gb
MERIT40 controls BRCA1-Rap80 c ...... nt to DNA double-strand breaks
@nl
prefLabel
MERIT40 controls BRCA1-Rap80 c ...... nt to DNA double-strand breaks
@ast
MERIT40 controls BRCA1-Rap80 c ...... nt to DNA double-strand breaks
@en
MERIT40 controls BRCA1-Rap80 c ...... nt to DNA double-strand breaks
@en-gb
MERIT40 controls BRCA1-Rap80 c ...... nt to DNA double-strand breaks
@nl
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MERIT40 controls BRCA1-Rap80 c ...... nt to DNA double-strand breaks
@en
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Genze Shao
Jeffrey Patterson-Fortin
Niraj Shanbhag
Roger A Greenberg
Troy E Messick
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P304
P3181
P356
10.1101/GAD.1739609
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P50
P577
2009-03-15T00:00:00Z