The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping
about
Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolatesAICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATICNew class of IMP cyclohydrolases in Methanococcus jannaschii.The crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase: mechanism of hydrolysis and its interplay with the dehydrogenase domainStructure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolaseA Novel Function for the N-Terminal Nucleophile Hydrolase Fold Demonstrated by the Structure of an Archaeal Inosine Monophosphate Cyclohydrolase † , ‡Crystal Structure and Function of 5-Formaminoimidazole-4-carboxamide Ribonucleotide Synthetase from Methanocaldococcus jannaschii † , ‡Structural Analyses of a Purine Biosynthetic Enzyme from Mycobacterium tuberculosis Reveal a Novel Bound NucleotideBiological and Structural Evaluation of 10 R - and 10 S -Methylthio-DDACTHF Reveals a New Role for Sulfur in Inhibition of Glycinamide Ribonucleotide TransformylaseCharacterization of two 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase isozymes from Saccharomyces cerevisiae.Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activityThe kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channelingA mathematical model of the folate cycle: new insights into folate homeostasis.Plasticity in the purine-thiamine metabolic network of Salmonella.The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL.Structural biology of the purine biosynthetic pathway.Tumor antigens as proteogenomic biomarkers in invasive ductal carcinomas.Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis.ATIC-ALK: A novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35).Transcriptomics Modeling of the Late-Gestation Fetal Pituitary Response to Transient HypoxiaAntibody-mediated targeting of CD45 isoforms: a novel immunotherapeutic strategy.Colocalization and Sequential Enzyme Activity in Aqueous Biphasic Systems: Experiments and Modeling.Promiscuous anaerobes: new and unconventional metabolism in methanogenic archaea.Evidence for the hypothesis that 10-formyldihydrofolate is the in vivo substrate for aminoimidazolecarboxamide ribotide transformylase.Nucleoside analogs and tuberculosis: new weapons against an old enemy.Aspartate 142 is involved in both hydrolase and dehydrogenase catalytic centers of 10-formyltetrahydrofolate dehydrogenase.Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) from Staphylococcus lugdunensis.On the role of conserved histidine 106 in 10-formyltetrahydrofolate dehydrogenase catalysis: connection between hydrolase and dehydrogenase mechanisms.Proteomic analysis of salivary glands of female Anopheles barbirostris species A2 (Diptera: Culicidae) by two-dimensional gel electrophoresis and mass spectrometry.Association of genetic polymorphisms of de novo nucleotide biosynthesis with increased CHD susceptibility in the northern Chinese population.Assignment of more than one gene to the same chromosome band on metaphase cytogenetics.Using logic programming for modeling the one-carbon metabolism network to study the impact of folate deficiency on methylation processes.AICAR + 10-Formyl-THF => FAICAR + THFFAICAR => IMP + H2O
P2860
Q24308109-C8A3A864-39BC-4046-B8D9-758DB02F1867Q24534042-0FA1FD50-7735-4BA7-9FF2-094CB4F2E90AQ24538840-EE3878C5-3DAF-4DA8-B375-29F72D3BC349Q27642970-59D82842-67A7-4A52-B721-344BBFD3A113Q27643913-8146F55E-5174-4FDA-9960-7F9A3C4881C3Q27644343-BDC996EC-6F59-410A-8559-F650664D3A40Q27649248-5A3F6B03-2EE0-4CC5-9363-F6D1A4372AF6Q27674579-CADD5C4E-88AC-4D10-9048-6AAB756BE0CCQ27679144-FDC84A66-7257-4726-BABE-1B331A5A4F87Q27930534-52F71ACF-36AA-46E1-9CDE-901CA1B4C4E7Q28138794-7D3794E3-C93C-4C82-BAA1-779E4FCC4566Q28214389-437CAA6C-EF09-477E-B68D-2CF9E4E1CCF4Q34360712-85386353-89BB-4C02-BA79-3AAC9878B542Q34537641-7675699F-249F-4853-A5B6-50FD9031CFDBQ34657347-7BF80823-95A8-4D05-917B-D714EAE857E8Q34810454-992E35E5-BDBD-40A4-BDFE-8F718C0F0652Q34914935-57458844-FD57-4BDC-BD29-774CEC422373Q35637808-C6285D76-93CB-4F1A-B10E-4C62C1580100Q35809839-8F8B99CD-F6BC-41F1-9D38-476DD923F9AAQ35918441-FED7FFDE-57AE-4622-A09E-ACF48AECDA1CQ36010833-E2A256B0-A4EE-489B-9E3E-08A2543DDB13Q36309700-EE582CEF-6BF0-43D4-AFF8-5304061FF3B9Q37039347-B91A97BC-CE84-47D6-8210-55529C0EBE7DQ37733989-02413A9C-7886-4688-A6C8-7104039568C5Q38397331-B2F09228-3DBD-4B35-A696-6221193DE296Q40914078-BF0E3EEF-249B-459E-BBDE-6CCA48FDBAE0Q42795860-1753B233-8CD1-4364-BACF-68708956D207Q43586924-7B3CEFF9-D8B3-4ABE-8772-7B500120F122Q44163984-33BE8064-9355-49BC-8A0A-21045440453EQ47272757-637DCA8B-8BEC-4567-A174-E5B7068D8065Q47373764-38C00762-E554-4636-89C1-840D61359264Q48655743-4026DEE0-06FA-4921-88E3-4A48FD15E313Q50294558-9A70F8B1-17AF-4D82-B4AA-377FB0527B9AQ50294559-8DFCBBB7-6BB5-4B94-B605-D25E1271B7DE
P2860
The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping
description
1996 nî lūn-bûn
@nan
1996 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
The human purH gene product, 5 ...... c analysis, and domain mapping
@ast
The human purH gene product, 5 ...... c analysis, and domain mapping
@en
The human purH gene product, 5 ...... c analysis, and domain mapping
@en-gb
The human purH gene product, 5 ...... c analysis, and domain mapping
@nl
type
label
The human purH gene product, 5 ...... c analysis, and domain mapping
@ast
The human purH gene product, 5 ...... c analysis, and domain mapping
@en
The human purH gene product, 5 ...... c analysis, and domain mapping
@en-gb
The human purH gene product, 5 ...... c analysis, and domain mapping
@nl
prefLabel
The human purH gene product, 5 ...... c analysis, and domain mapping
@ast
The human purH gene product, 5 ...... c analysis, and domain mapping
@en
The human purH gene product, 5 ...... c analysis, and domain mapping
@en-gb
The human purH gene product, 5 ...... c analysis, and domain mapping
@nl
P2093
P2860
P356
P1476
The human purH gene product, 5 ...... c analysis, and domain mapping
@en
P2093
B A Moroson
G P Beardsley
P2860
P304
P356
10.1074/JBC.271.4.2225
P407
P577
1996-01-26T00:00:00Z