The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation
about
Mutational activation of the MAP3K8 protooncogene in lung cancerNF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activityProstaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activationActivation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinaseExpression of the Tpl2/Cot oncogene in human T-cell neoplasiasRegulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinaseTpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinasesPhosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3).Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice.Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105.Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages.IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400BCL11B enhances TCR/CD28-triggered NF-kappaB activation through up-regulation of Cot kinase gene expression in T-lymphocytes.Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.The role of hybrid ubiquitin chains in the MyD88 and other innate immune signalling pathways.Tpl2 promotes neutrophil trafficking, oxidative burst, and bacterial killing.Tumor progression locus 2-dependent oxidative burst drives phosphorylation of extracellular signal-regulated kinase during TLR3 and 9 signaling.
P2860
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P2860
The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation
description
1993 nî lūn-bûn
@nan
1993 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
The human cot proto-oncogene e ...... tive initiation of translation
@ast
The human cot proto-oncogene e ...... tive initiation of translation
@en
The human cot proto-oncogene e ...... tive initiation of translation
@en-gb
The human cot proto-oncogene e ...... tive initiation of translation
@nl
type
label
The human cot proto-oncogene e ...... tive initiation of translation
@ast
The human cot proto-oncogene e ...... tive initiation of translation
@en
The human cot proto-oncogene e ...... tive initiation of translation
@en-gb
The human cot proto-oncogene e ...... tive initiation of translation
@nl
prefLabel
The human cot proto-oncogene e ...... tive initiation of translation
@ast
The human cot proto-oncogene e ...... tive initiation of translation
@en
The human cot proto-oncogene e ...... tive initiation of translation
@en-gb
The human cot proto-oncogene e ...... tive initiation of translation
@nl
P2093
P1476
The human cot proto-oncogene e ...... tive initiation of translation
@en
P2093
P304
22723-22732
P407
P577
1993-10-01T00:00:00Z