Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.
about
HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interactionInteraction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradationBlockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myelomaDangER: protein ovERload. Targeting protein degradation to treat myelomaTargeting heat shock proteins to modulate α-synuclein toxicityGRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulumXenobiotic perturbation of ER stress and the unfolded protein responseCo-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.Novel therapeutic strategies for multiple myelomaDynamic impacts of the inhibition of the molecular chaperone Hsp90 on the T-cell proteome have implications for anti-cancer therapyHeat shock proteins: cellular and molecular mechanisms in the central nervous system.Hsp90 inhibition decreases mitochondrial protein turnover.Suppression of heat shock protein 27 using OGX-427 induces endoplasmic reticulum stress and potentiates heat shock protein 90 inhibitors to delay castrate-resistant prostate cancer.Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans.Endoplasmic reticulum stress and cancer.The Unfolded Protein Response, Degradation from Endoplasmic Reticulum and CancerSynthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cellsSigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survivalMitoxosome: a mitochondrial platform for cross-talk between cellular stress and antiviral signaling.Ras, ROS and proteotoxic stress: a delicate balance.Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells.A review of the mammalian unfolded protein response.Cdc37/Hsp90 protein-mediated regulation of IRE1α protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells.Disruption of the ribosomal P complex leads to stress-induced autophagy.HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activationUnfolded protein response to autophagy as a promising druggable target for anticancer therapy.Restoration of lung surfactant protein D by IL-6 protects against secondary pneumonia following hemorrhagic shockTumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy.Novel role of HAX-1 in ischemic injury protection involvement of heat shock protein 90ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complexHsp90 regulates the phosphorylation and activity of serum- and glucocorticoid-regulated kinase-1.Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes.Structure, biochemistry and biology of hepoxilins: an update.Nonapoptotic death of Saccharomyces cerevisiae cells that is stimulated by Hsp90 and inhibited by calcineurin and Cmk2 in response to endoplasmic reticulum stresses.IRE1: ER stress sensor and cell fate executor.Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome.Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities.Monitoring and manipulating mammalian unfolded protein response.Heat shock proteins in multiple myelomaFactors involved in CLL pathogenesis and cell survival are disrupted by differentiation of CLL B-cells into antibody-secreting cells.
P2860
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P2860
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
name
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha
@nl
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.
@ast
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.
@en
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.
@en-gb
type
label
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha
@nl
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.
@ast
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.
@en
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.
@en-gb
prefLabel
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha
@nl
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.
@ast
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.
@en
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.
@en-gb
P2093
P2860
P921
P1476
Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.
@en
P2093
Len Neckers
Linda Hendershot
Melissa Doyle
Monica G Marcu
P2860
P304
P356
10.1128/MCB.22.24.8506-8513.2002
P407
P577
2002-12-01T00:00:00Z