Redox modification of nuclear actin by MICAL-2 regulates SRF signaling
about
Regulation of protein function by reversible methionine oxidation and the role of selenoprotein MsrB1Regulation of signal transduction by reactive oxygen species in the cardiovascular systemThe intracellular redox protein MICAL-1 regulates the development of hippocampal mossy fibre connectionsMyocardin-Related Transcription Factor A Activation by Competition with WH2 Domain Proteins for Actin Binding.F-actin dismantling through a redox-driven synergy between Mical and cofilin.The Effects of Disease Models of Nuclear Actin Polymerization on the Nucleus.Oxidation of F-actin controls the terminal steps of cytokinesis.Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury.Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis.Cellular mechanisms of tissue fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription.Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection.MRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development.Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related Transcription Factor A.DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-½ that promotes efficient DNA repair. [corrected].MICAL2 is a novel human cancer gene controlling mesenchymal to epithelial transition involved in cancer growth and invasion.Myocardin-related transcription factor A (MRTFA) regulates the fate of bone marrow mesenchymal stem cells and its absence in mice leads to osteopenia.Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes.RhoA/ROCK signaling regulates TGFβ-induced epithelial-mesenchymal transition of lens epithelial cells through MRTF-ACellular Levels of Signaling Factors Are Sensed by β-actin Alleles to Modulate Transcriptional Pulse Intensity.Redox regulation of vascular remodeling.The myocardin-related transcription factor MKL co-regulates the cellular levels of two profilin isoforms.MRTF potentiates TEAD-YAP transcriptional activity causing metastasis.Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma.Dissecting the role of redox signaling in neuronal development.Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration.Actin filaments-A target for redox regulationModulation of MICAL Monooxygenase Activity by its Calponin Homology Domain: Structural and Mechanistic Insights.Regulated methionine oxidation by monooxygenases.Redox regulation of the actin cytoskeleton and its role in the vascular system.Reactive oxygen species and hydrogen peroxide generation in cell migration.MRTFs- master regulators of EMT.Persistent nuclear actin filaments inhibit transcription by RNA polymerase II.Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor.Catastrophic disassembly of actin filaments via Mical-mediated oxidation.Characterizing F-actin Disassembly Induced by the Semaphorin-Signaling Component MICAL.From Cytoskeleton to Gene Expression: Actin in the Nucleus.Initiation of DNA replication requires actin dynamics and formin activity.The MICALs are a Family of F-actin Dismantling Oxidoreductases Conserved from Drosophila to Humans.Overexpression of MICAL2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and EMT.MICAL2 promotes breast cancer cell migration by maintaining epidermal growth factor receptor (EGFR) stability and EGFR/P38 signalling activation.
P2860
Q28084740-4ADC05BF-257D-4BA4-9B84-1FFEAC38467FQ28391569-BC480CAF-AA4A-41E6-9B37-A10080C3078AQ28975620-074A1D8D-A294-41E1-99F2-409E6AC1582BQ30315430-4EEEFA4C-6C87-4FAE-B21F-CC385B28A418Q30791894-090B2DE8-16F0-4D71-BABD-156AE957F075Q30819346-DC1E0299-B0DA-4CAB-8431-85C4C26F5F35Q30840206-5461D7A4-BE2C-4B58-8FD7-370EE34472DFQ33603627-1E8CD351-8911-42D1-98FF-36D27714F7F0Q33670231-C818E88E-AF14-441A-B640-53C63E5D684FQ33840143-B92F3A30-5C3F-42B2-A500-4A703FA77699Q34150494-A97A78B7-A8B5-49DA-B205-85445AD5D2C8Q35103545-D2B2DB4D-A0FF-4BED-95F6-2112C6869EBFQ35752038-BD79F437-5C75-456A-A1EA-FA78D9F3E42AQ36080669-B6498D81-6040-4ACB-BDF6-E94811DB43EEQ36738978-1B4840D4-1715-4A9F-8EAB-46EB2212EA8EQ37279035-9829AF3F-E0D0-46A8-9B6E-96CCE39BFF65Q37408633-A97CBEB0-D98D-4BDB-895E-79A4A968B227Q37468691-AF41D8C2-91EC-4AAF-A47C-3DB550ECB16EQ38267100-F1F65CBD-69C6-4DCB-BBFC-EFC093DC6700Q38611682-D8ED4AFA-84F7-4A94-8E6B-153589DC0CB0Q38702210-C54FE896-6A06-4715-B9EF-C1A2E7A84F0FQ38724065-5D7A7DD3-DD37-4F03-9E3F-7437369B0695Q38731620-4F0996AE-7570-414E-B9F9-82C908C2CE68Q38733068-0D44C095-B860-4A79-860C-A0F0CFF1277AQ38820486-F6BD79E0-4DAC-4CC1-BBB5-B442DA483DCAQ38866879-1003CF7B-19E4-439C-A69B-41FBA358F7C2Q39010064-0E611FF6-DC2F-409A-9DDE-7B3BB7E7706CQ39147645-25E5FA1A-3F82-4D4C-9124-5F1667FF2314Q39174495-D386B703-4A19-4F2B-BF52-A0DA1D1F90BBQ39328405-F7C9738C-E822-4061-A36E-2FB5B96268CAQ39417565-CC58AA0D-0D88-43BE-B0CA-997DB7207B32Q39507496-A2A3FC7B-4503-4A17-B29A-17A1012E241CQ45998425-44E86D7A-1781-423A-9335-8126634FC6C3Q47101663-D1462A9D-B923-4DAC-8D91-A11B49DBE732Q47118374-9F4DB38F-347D-4319-BF48-46E82A87FAA7Q47189714-AFB93407-453B-4728-90AB-9748E42C950DQ47690463-3F19C1D0-873F-4D48-B660-76C54C708913Q49988888-52C3CA09-426C-4663-BD4B-AB6A3181B945Q50311627-D975E280-5F72-4A98-AC43-76CD68F047DAQ50884256-7B9C70A9-8BDF-4DCC-BFEA-71C4B6964FC6
P2860
Redox modification of nuclear actin by MICAL-2 regulates SRF signaling
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Redox modification of nuclear actin by MICAL-2 regulates SRF signaling
@ast
Redox modification of nuclear actin by MICAL-2 regulates SRF signaling
@en
Redox modification of nuclear actin by MICAL-2 regulates SRF signaling
@en-gb
Redox modification of nuclear actin by MICAL-2 regulates SRF signaling
@nl
type
label
Redox modification of nuclear actin by MICAL-2 regulates SRF signaling
@ast
Redox modification of nuclear actin by MICAL-2 regulates SRF signaling
@en
Redox modification of nuclear actin by MICAL-2 regulates SRF signaling
@en-gb
Redox modification of nuclear actin by MICAL-2 regulates SRF signaling
@nl
prefLabel
Redox modification of nuclear actin by MICAL-2 regulates SRF signaling
@ast
Redox modification of nuclear actin by MICAL-2 regulates SRF signaling
@en
Redox modification of nuclear actin by MICAL-2 regulates SRF signaling
@en-gb
Redox modification of nuclear actin by MICAL-2 regulates SRF signaling
@nl
P2093
P2860
P921
P3181
P1433
P1476
Redox modification of nuclear actin by MICAL-2 regulates SRF signaling
@en
P2093
Andrew J Storaska
Mark R Lundquist
Samie R Jaffrey
Scott D Larsen
Ting-Chun Liu
Todd Evans
P2860
P304
P3181
P356
10.1016/J.CELL.2013.12.035
P407
P50
P577
2014-01-16T00:00:00Z