Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide
about
Characterization of C-Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH-1Inhibitors of the Hydrolytic Enzyme Dimethylarginine Dimethylaminohydrolase (DDAH): Discovery, Synthesis and DevelopmentZinc-binding cysteines: diverse functions and structural motifs.Mechanistic similarity and diversity among the guanidine-modifying members of the pentein superfamily.A continuous, fluorescent, high-throughput assay for human dimethylarginine dimethylaminohydrolase-1On-resin synthesis of novel arginine-isostere peptides bearing substituted amidine headgroups.Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.Development of a dimethylarginine dimethylaminohydrolase (DDAH) assay for high-throughput chemical screening.Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide.Developing an irreversible inhibitor of human DDAH-1, an enzyme upregulated in melanoma.Screening for dimethylarginine dimethylaminohydrolase inhibitors reveals ebselen as a bioavailable inactivatorA click chemistry mediated in vivo activity probe for dimethylarginine dimethylaminohydrolase.Ligand-dependent dynamics of the active-site lid in bacterial dimethylarginine dimethylaminohydrolase.Biological activities of guanidine compounds, 2008 - 2012 update.Selective Covalent Protein Modification by 4-Halopyridines through Catalysis.Site-specific and regiospecific installation of methylarginine analogues into recombinant histones and insights into effector protein bindingDDAH: a target for vascular therapy?Dimethylarginine-dimethylaminohydrolase-2 (DDAH-2) does not metabolize methylarginines.DDAH1;2 hydrolyses ADMA to DMA and L-Cit
P2860
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P2860
Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Developing dual and specific i ...... cology to control nitric oxide
@ast
Developing dual and specific i ...... cology to control nitric oxide
@en
Developing dual and specific i ...... cology to control nitric oxide
@en-gb
Developing dual and specific i ...... cology to control nitric oxide
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type
label
Developing dual and specific i ...... cology to control nitric oxide
@ast
Developing dual and specific i ...... cology to control nitric oxide
@en
Developing dual and specific i ...... cology to control nitric oxide
@en-gb
Developing dual and specific i ...... cology to control nitric oxide
@nl
altLabel
Developing Dual and Specific I ...... cology To Control Nitric Oxide
@en
prefLabel
Developing dual and specific i ...... cology to control nitric oxide
@ast
Developing dual and specific i ...... cology to control nitric oxide
@en
Developing dual and specific i ...... cology to control nitric oxide
@en-gb
Developing dual and specific i ...... cology to control nitric oxide
@nl
P2093
P2860
P356
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Developing dual and specific i ...... cology to control nitric oxide
@en
P2093
Arthur F Monzingo
Jon D Robertus
Shougang Hu
Tera H Schaller
Walter Fast
P2860
P304
P356
10.1021/BI9007098
P407
P577
2009-09-15T00:00:00Z