A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
about
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activationThe essential role of profilin in the assembly of actin for microspike formation.Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' proteinStructure of the small G protein Cdc42 bound to the GTPase-binding domain of ACKMelanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130casGene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent streCdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylationSPECs, small binding proteins for Cdc42Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actinPhosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinaseExpression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 bindingA conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPasesRegulation of Ack1 localization and activity by the amino-terminal SAM domainAck1 mediates Cdc42-dependent cell migration and signaling to p130CasShepherding AKT and androgen receptor by Ack1 tyrosine kinaseThe Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formationThe Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPasesMyotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganizationConstitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynaminInduction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASPIdentification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinaseActivated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradationInhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domainSelection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexesThe Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeletonAn SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinaseAssociation of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteinsAck1: Activation and Regulation by AllosteryCrystal structure of human RhoA in a dominantly active form complexed with a GTP analogueZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae.Interactions between the bud emergence proteins Bem1p and Bem2p and Rho-type GTPases in yeastCdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinaseStimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated kinase-1 via a Fyn tyrosine kinase signaling pathwayStimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42Mig-6 is a negative regulator of the epidermal growth factor receptor signal
P2860
Q21142629-5FD8D657-1C66-4F4A-A36A-8C02C65B86EEQ22008023-CC7F7BDA-63E6-4E12-8521-A7220322F0EAQ22009957-F8ADD1DF-AFCF-4102-802F-4CAAB2B6BA43Q22009973-75BD8B96-B5D8-4C18-A256-1834407A3EC7Q22010904-20907C7B-90FA-4F02-A3E0-E0167798115EQ22253460-8CC58E76-147C-47E3-BA8B-E0BA57FCDC23Q22254031-4440C2F8-FBFE-488E-9FB9-CB1416DC1BFDQ22254115-8825056B-F8C0-4941-8581-E9B6D122BE38Q24290738-D1E5AE27-D1A7-4285-8CD1-6C144BE13162Q24293090-FA7D9529-C718-4AC0-9107-413E8BB84496Q24296656-9839D39D-FCD5-4205-BDDF-92E3F3FAAA67Q24304128-5D780C47-3AF1-40BE-8424-4DB503C0FB0AQ24304469-5C3285F9-144F-4478-A910-73CE7F64B58FQ24306771-772E91D5-845B-4F82-B447-74C29F93B774Q24308859-B9CA1003-38B0-41A7-96BC-146C489A00B5Q24313611-F75A7D27-6183-4E57-A288-E695B0C4715BQ24316220-593E7A1E-E077-424D-8684-45CF7FA9EACEQ24317262-898F3186-69A0-4AA0-98C6-DE414DADB208Q24317755-0FAF93A0-3853-462B-B87C-B9605E133FBFQ24318478-DAE133E9-3016-4430-8DC6-752C7AE871F1Q24321633-0DC7C60F-1D62-44CD-AB12-62D4C2A862E3Q24337716-9CCC7216-88F4-4D83-B24E-52F6F51F7077Q24551173-E5F29232-2BDF-4E8B-9E82-DE24376482D4Q24562305-DBCA48D5-3C3E-4684-AB1E-20EFC0CC8456Q24603554-E069CC4C-7533-423D-B6C1-7E04F3C17DE7Q24647211-7B5B528B-D480-4DDF-98CF-D9E6432BD0A2Q24647927-67C86443-7336-452F-A4CC-DEBA1D9A84DAQ24648481-FCE0F053-8148-4CF1-8D11-C3ADEE38B3EDQ24648985-9CAFFCA1-15BF-4BE0-96C4-6BF22DA80238Q24652816-C0C1BFAD-FF40-4D42-9545-3101F910473BQ27675970-37234854-2947-4CF6-979A-F8C9CF9E7B68Q27749065-8B25DD34-75AB-4A54-B7C8-CF0FF62AE273Q27929841-84F7A355-9DA5-4D74-9FFB-FEBE91CF7BB3Q27937191-CA508749-E6E5-4D05-83DB-ABEB01C4E403Q27939243-9C1C3CF8-9432-4EC4-8606-0E8E3A0542AAQ28117594-CCAB7859-F3B0-46A3-A7ED-8FB4BAD5631DQ28138302-EBB23E94-D636-4B82-AE5F-5C0988DA370DQ28140083-761ADCD9-4645-42C8-8098-FC35C58270DDQ28146238-EB4F7940-E9B0-472C-ADFB-77DA5C4E0A82Q28201153-DAFCE1A7-B407-483E-AE1B-9AA819A20582
P2860
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
description
1993 nî lūn-bûn
@nan
1993 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
@ast
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
@en
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
@en-gb
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
@nl
type
label
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
@ast
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
@en
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
@en-gb
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
@nl
prefLabel
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
@ast
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
@en
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
@en-gb
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
@nl
P2093
P3181
P356
P1433
P1476
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
@en
P2093
P2888
P3181
P356
10.1038/363364A0
P407
P577
1993-05-27T00:00:00Z
P6179
1039777366