Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR
about
Ser/ Thr residues at α3/β5 loop of Gαs are important in morphine-induced adenylyl cyclase sensitization but not mitogen-activated protein kinase phosphorylationBeta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signallingG protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei--serpentine gateways to neuroendocrine homeostasisBeta-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transductionHigh-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptorTargeting G protein coupled receptor-related pathways as emerging molecular therapiesCrystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal stateLabel-free integrative pharmacology on-target of opioid ligands at the opioid receptor familyDuplexed label-free G protein--coupled receptor assays for high-throughput screening.PP2 prevents β-adrenergic stimulation of cardiac pacemaker activity.Ligand-directed signalling at beta-adrenoceptorsSrc family kinases participate in the regulation of encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophagesDissociations in the effects of β2-adrenergic receptor agonists on cAMP formation and superoxide production in human neutrophils: support for the concept of functional selectivity.Pivotal role of extended linker 2 in the activation of Gα by G protein-coupled receptor.Activation of the galanin receptor 2 in the periphery reverses nerve injury-induced allodynia.Serelaxin-mediated signal transduction in human vascular cells: bell-shaped concentration-response curves reflect differential coupling to G proteinsIsoproterenol acts as a biased agonist of the alpha-1A-adrenoceptor that selectively activates the MAPK/ERK pathway.5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling.Studies of the regulation and function of the Gs alpha gene Gnas using gene targeting technology.EP2 Induces p38 Phosphorylation via the Activation of Src in HEK 293 Cells.Critical Roles of STAT3 in β-Adrenergic Functions in the Heartbeta-Adrenergic receptor activation induces internalization of cardiac Cav1.2 channel complexes through a beta-arrestin 1-mediated pathwayDual effect of morphine in long-term social memory in rat.Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytesPinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes.Atypical chemokine receptorsFunctional selectivity of adenosine receptor ligandsA perspective on more effective GPCR-targeted drug discovery efforts.cAMP inhibits cell migration by interfering with Rac-induced lamellipodium formation.Coagulation and non-coagulation effects of thrombin.Intracellular distribution of functional M(1) -muscarinic acetylcholine receptors in N1E-115 neuroblastoma cells.G protein-coupled receptor signaling via Src kinase induces endogenous human transient receptor potential vanilloid type 6 (TRPV6) channel activation.A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17.A 100K well screen for a muscarinic receptor using the Epic label-free system--a reflection on the benefits of the label-free approach to screening seven-transmembrane receptors.Src phosphorylation of micro-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal.Label-free optical biosensor for ligand-directed functional selectivity acting on beta(2) adrenoceptor in living cells.Optical biosensor differentiates signaling of endogenous PAR1 and PAR2 in A431 cells.Conformational thermostabilisation of corticotropin releasing factor receptor 1.A systemic Pasteurella multocida toxin aggravates cardiac hypertrophy and fibrosis in mice.Cell contact-dependent functional selectivity of β2-adrenergic receptor ligands in stimulating cAMP accumulation and extracellular signal-regulated kinase phosphorylation
P2860
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P2860
Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Dosage-dependent switch from G ...... ndependent signaling by a GPCR
@ast
Dosage-dependent switch from G ...... ndependent signaling by a GPCR
@en
Dosage-dependent switch from G ...... ndependent signaling by a GPCR
@en-gb
Dosage-dependent switch from G ...... ndependent signaling by a GPCR
@nl
type
label
Dosage-dependent switch from G ...... ndependent signaling by a GPCR
@ast
Dosage-dependent switch from G ...... ndependent signaling by a GPCR
@en
Dosage-dependent switch from G ...... ndependent signaling by a GPCR
@en-gb
Dosage-dependent switch from G ...... ndependent signaling by a GPCR
@nl
prefLabel
Dosage-dependent switch from G ...... ndependent signaling by a GPCR
@ast
Dosage-dependent switch from G ...... ndependent signaling by a GPCR
@en
Dosage-dependent switch from G ...... ndependent signaling by a GPCR
@en-gb
Dosage-dependent switch from G ...... ndependent signaling by a GPCR
@nl
P2093
P2860
P356
P1433
P1476
Dosage-dependent switch from G ...... ndependent signaling by a GPCR
@en
P2093
Harald Jüppner
J Jillian Zhang
Jianyun Huang
Murat Bastepe
Xin-Yun Huang
Yang Xiang
Yutong Sun
P2860
P356
10.1038/SJ.EMBOJ.7601502
P407
P577
2007-01-10T00:00:00Z