A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling
about
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protectionStructural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 SignalingFine tuning inflammation at the front door: macrophage complement receptor 3-mediates phagocytosis and immune suppression for Francisella tularensisA promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction.Meet me halfway: when genomics meets structural bioinformatics.SDM--a server for predicting effects of mutations on protein stability and malfunction.The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival.Phosphoinositide turnover in Toll-like receptor signaling and trafficking.Formal modelling of toll like receptor 4 and JAK/STAT signalling pathways: insight into the roles of SOCS-1, interferon-β and proinflammatory cytokines in sepsisR753Q polymorphism inhibits Toll-like receptor (TLR) 2 tyrosine phosphorylation, dimerization with TLR6, and recruitment of myeloid differentiation primary response protein 88MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.Pattern recognition receptors: sentinels in innate immunity and targets of new vaccine adjuvants.Mal, more than a bridge to MyD88.Beyond TLR Signaling—The Role of SARM in Antiviral Immune Defense, Apoptosis & Development.The small GTPase Arf6 is essential for the Tram/Trif pathway in TLR4 signaling.Coactivation of TLR4 and TLR2/6 coordinates an additive augmentation on IL-6 gene transcription via p38MAPK pathway in U937 mononuclear cells.Identification of binding sites for myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 in MyD88 adapter-like (Mal).The effect of n-3/n-6 polyunsaturated fatty acids on acute reflux esophagitis in rats.ARC Syndrome-Linked Vps33B Protein Is Required for Inflammatory Endosomal Maturation and Signal Termination.The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF.Identification of a Toll-like receptor 1 in guinea fowl (Agelastes niger).Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form Myddosomes.Evolution of the TIR domain-containing adaptors in humans: swinging between constraint and adaptation.A TIR domain receptor-associated protein (TIRAP) variant SNP (rs8177374) confers protection against premature birth.TIRAP binds PIP2-rich regions in the plasma membraneCytotoxicity against tumor cell lines and anti-inflammatory properties of chitinases from Calotropis procera latex.Restricting HIV the SAMHD1 way: through nucleotide starvation.
P2860
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P2860
A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A TIR domain variant of MyD88 ...... nd reduced TLR2/TLR4 signaling
@ast
A TIR domain variant of MyD88 ...... nd reduced TLR2/TLR4 signaling
@en
A TIR domain variant of MyD88 ...... nd reduced TLR2/TLR4 signaling
@en-gb
A TIR domain variant of MyD88 ...... nd reduced TLR2/TLR4 signaling
@nl
type
label
A TIR domain variant of MyD88 ...... nd reduced TLR2/TLR4 signaling
@ast
A TIR domain variant of MyD88 ...... nd reduced TLR2/TLR4 signaling
@en
A TIR domain variant of MyD88 ...... nd reduced TLR2/TLR4 signaling
@en-gb
A TIR domain variant of MyD88 ...... nd reduced TLR2/TLR4 signaling
@nl
prefLabel
A TIR domain variant of MyD88 ...... nd reduced TLR2/TLR4 signaling
@ast
A TIR domain variant of MyD88 ...... nd reduced TLR2/TLR4 signaling
@en
A TIR domain variant of MyD88 ...... nd reduced TLR2/TLR4 signaling
@en-gb
A TIR domain variant of MyD88 ...... nd reduced TLR2/TLR4 signaling
@nl
P2093
P2860
P921
P3181
P356
P1476
A TIR domain variant of MyD88 ...... nd reduced TLR2/TLR4 signaling
@en
P2093
Brian G Monks
Douglas T Golenbock
Joyce Wong
Kamalpreet Nagpal
Katherine A Fitzgerald
Mihai G Netea
Nicholas J Gay
Theo S Plantinga
P2860
P304
P3181
P356
10.1074/JBC.M109.014886
P407
P577
2009-09-18T00:00:00Z